70380-73-3

Basic information

• Product Name: 5-(2-PYRIDYL)-1,3-OXAZOLE
• Synonyms: 5-(2-PYRIDYL)-1,3-OXAZOLE;BUTTPARK 145\08-78;5-(Pyridin-2-yl)-1,3-oxazole;5-(PYRID-2-YL)OXAZOLE;2-Oxazol-5-yl-pyridine;5-(Pyrid-2-yl)1,3-oxazole;2-(5-oxazolyl)pyridine;5-(pyridin-2-yl)oxazole
• CAS NO: 70380-73-3
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.15
• Mol File: 70380-73-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 279.1 °C at 760 mmHg
• Flash Point: 129.7 °C
• Appearance: /
• Density: 1.179 g/cm³
• Vapor Pressure: 0.00692mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 5-(2-PYRIDYL)-1,3-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-PYRIDYL)-1,3-OXAZOLE(70380-73-3)
• EPA Substance Registry System: 5-(2-PYRIDYL)-1,3-OXAZOLE(70380-73-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 70380-73-3(Hazardous Substances Data)

Usage

General Description

5-(2-Pyridyl)-1,3-oxazole is a chemical compound with the molecular formula C9H7N2O. It is a heterocyclic organic compound containing a pyridine ring and an oxazole ring. 5-(2-PYRIDYL)-1,3-OXAZOLE is commonly used in pharmaceutical and organic synthesis, as it serves as a building block for various pharmaceutical drugs and fine chemicals. It exhibits biological activities such as antibacterial, antifungal, and anticancer properties, making it a valuable compound in drug development. Additionally, it is used as a fluorescent indicator in analytical chemistry and as a ligand in coordination chemistry. This chemical is flammable and should be handled with care in a controlled laboratory environment.

InChI:InChI=1/C8H6N2O/c1-2-4-10-7(3-1)8-5-9-6-11-8/h1-6H

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 10564-55-3 1-isocyanatomethanesulfonyl-4-methyl-benzene 
• 109-04-6 2-bromo-pyridine 
• 1186127-11-6 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)-1,3-oxazole 
• 288-42-6 oxazol 
• 109-09-1 2-chloropyridine 
• 586-98-1 2-Hydroxymethylpyridine 

Downstream Products

• 681135-77-3 OL-135 
• 945414-31-3 tert-butyl 4-(3-oxo-3-(5-(pyridin-2-yl)oxazol-2-yl)propyl)phenyl(phenyl)carbamate 

Relevant articles and documents

Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells

In the search for new fluorescent triphenylamine (TP) derivatives, we studied the influence of the position and substitution of diverse heterocyclic substituents. A library of 10 fluorescent triphenylamines bearing either oxazoles or thiazoles and pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C?H activation reaction between pyridine-oxazoles or pyridine-thiazoles and di-iodo triphenylamine. We showed that the nature and substitution pattern of the 5-membered- (oxazole, thiazole) or 6-membered heterocycle (pyridine) has a strong influence on their fluorescence properties and on their localization in living cells as they stain either the nucleus or mitochondria.

Improvement of the Van Leusen reaction in the presence of β-cyclodextrin: A green and efficient synthesis of oxazoles in water

An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of β-cyclodextrin is described. In aqueous medium using β-cyclodextrin as a supramolecular catalyst, tosylmethyl isocyanide was deprotonated by triethylami

Linear and Branched Pyridyl-Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c-Myc G-Quadruplex Helicity

Five unprecedented pyridyl-oxazole oligomers exhibiting either linear or branched connectivity of their subunits were developed as a family of potential G-quadruplex-interacting ligands. Our synthesis employed variations of a key Pd/Cu-mediated C-C cross-coupling/C-H activation reaction to gain access to the oligomer products from a small set of substituted pyridine building blocks. The effect of the compounds on the conformation of a c-myc oncogene promoter G-quadruplex was investigated by circular dichroism under various conditions. Some or all of the compounds induced detectable helicity enhancement in low-cation and Na+-rich Tris-HCl (pH 7.4) buffers, respectively, in which the helix was only partially prefolded.