70380-74-4

Basic information

• Product Name: 5-(3-PYRIDYL)-1,3-OXAZOLE
• Synonyms: 5-(3-PYRIDYL)-1,3-OXAZOLE;5-(Pyridin-3-yl)-1,3-oxazole;5-(PYRID-3-YL)OXAZOLE;3-(1,3-Oxazol-5-yl)pyridine;3-Oxazol-5-yl-pyridine;5-(Pyridin-3-yl)oxazole
• CAS NO: 70380-74-4
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.15
• Product Categories: Oxazoles, Isoxazoles & Benzoxazoles
• Mol File: 70380-74-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 60-62
• Boiling Point: 291.7 °C at 760 mmHg
• Flash Point: 138.9 °C
• Appearance: /
• Density: 1.179 g/cm³
• Vapor Pressure: 0.00335mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 5-(3-PYRIDYL)-1,3-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-PYRIDYL)-1,3-OXAZOLE(70380-74-4)
• EPA Substance Registry System: 5-(3-PYRIDYL)-1,3-OXAZOLE(70380-74-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 70380-74-4(Hazardous Substances Data)

Usage

General Description

5-(3-Pyridyl)-1,3-oxazole is a chemical compound with the molecular formula C8H6N2O. It is a heterocyclic compound that contains both nitrogen and oxygen atoms in its five-membered ring structure. 5-(3-PYRIDYL)-1,3-OXAZOLE is commonly used in medicinal chemistry as a building block for the synthesis of pharmaceutical drugs, particularly as a scaffold for potential antimicrobial agents. It has also been studied for its potential as an anti-tumor agent and as a fluorescent probe for the detection of metal ions. 5-(3-Pyridyl)-1,3-oxazole is a versatile compound with a range of potential applications in the fields of medicine and materials science.

InChI:InChI=1/C8H6N2O/c1-2-7(4-9-3-1)8-5-10-6-11-8/h1-6H

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 87022-42-2 1-(isocyanomethyl)-1H-benzo[d][1,2,3]triazole 
• 195711-05-8 1-(isocyanomethyloxy)benzotriazole 
• 626-55-1 3-Bromopyridine 
• 1186127-11-6 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(triisopropylsilyl)-1,3-oxazole 
• 288-42-6 oxazol 

Downstream Products

• 342601-37-0 C₉H₆N₂O₂ 
• 1020264-31-6 5-(Pyridine-3-yl)-2-(p-tolyl)oxazole 

Relevant articles and documents

Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells

In the search for new fluorescent triphenylamine (TP) derivatives, we studied the influence of the position and substitution of diverse heterocyclic substituents. A library of 10 fluorescent triphenylamines bearing either oxazoles or thiazoles and pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C?H activation reaction between pyridine-oxazoles or pyridine-thiazoles and di-iodo triphenylamine. We showed that the nature and substitution pattern of the 5-membered- (oxazole, thiazole) or 6-membered heterocycle (pyridine) has a strong influence on their fluorescence properties and on their localization in living cells as they stain either the nucleus or mitochondria.

Improvement of the Van Leusen reaction in the presence of β-cyclodextrin: A green and efficient synthesis of oxazoles in water

An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of β-cyclodextrin is described. In aqueous medium using β-cyclodextrin as a supramolecular catalyst, tosylmethyl isocyanide was deprotonated by triethylami

Synthesis of 2,5-diaryloxazoles through van Leusen reaction and copper-mediated direct arylation

The direct arylation of 5-aryloxazoles, prepared by the van Leusen reaction, with various aryl iodides is effectively promoted by a system of CuI combined with PPh3 and Na2CO3 as a ligand and a base, respectively, in DMF to produce the corresponding 2,5-diaryloxazoles in good yields.