70396-27-9

Basic information

• Product Name: Boc-L-phenylalanyl-L-alanyl-L-alanine methyl ester
• Synonyms: Boc-L-phenylalanyl-L-alanyl-L-alanine methyl ester
• CAS NO: 70396-27-9
• Molecular Weight: 421.494
• Mol File: 70396-27-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Boc-L-phenylalanyl-L-alanyl-L-alanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-phenylalanyl-L-alanyl-L-alanine methyl ester(70396-27-9)
• EPA Substance Registry System: Boc-L-phenylalanyl-L-alanyl-L-alanine methyl ester(70396-27-9)

Safety Data

• Hazardous Substances Data: 70396-27-9(Hazardous Substances Data)

Upstream product

• 1345827-07-7 C₁₇H₂₂N₂O₄S 
• 19794-10-6 (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 41036-19-5 L-alanyl-alanine methylester hydrochloride 
• 64516-01-4 alanylalanine methyl ester trifluoroacetate 

Relevant articles and documents

Coupling of sterically demanding peptides by β-thiolactone-mediated native chemical ligation

The ligation of sterically demanding peptidyl sites such as those involving Val-Val and Val-Pro linkages has proven to be extremely challenging with conventional NCL methods that rely on exogenous thiol additives. Herein, we report an efficient β-thiolactone-mediated additive-free NCL protocol that enables the establishment of these connections in good yield. The rapid NCL was followed by in situ desulfurization. Reaction rates between β-thiolactones and conventional thioesters towards NCL were also investigated, and direct aminolysis was ruled out as a possible pathway. Finally, the potent cytotoxic cyclic-peptide axinastatin 1 has been prepared using the developed methodology.

SEGMENT COUPLING IN PEPTIDE SYTHESIS-II A SIMPLE PREDICTIVE EQUATION CORRELATING RACEMIZATION AND PRIMARY STRUCTURE

A predictive equation based on extrathermodynamic assumptions is proposed, that allows the prediction of the degree of epimerization in tripeptide model reactions of condensation of peptide segments as a function of the primary structure.The experimental