70398-89-9

Basic information

• Product Name: 1-BroMo-4-isopropylsulfanyl-benzene
• Synonyms: 1-BroMo-4-isopropylsulfanyl-benzene;1-Bromo-4-(isopropylthio)benzene;1-Bromo-4-(propan-2-ylsulphanyl)benzene;1-BROMO-4-(PROPAN-2-YLSULFANYL)BENZENE
• CAS NO: 70398-89-9
• Molecular Formula: C₉H₁₁BrS
• Molecular Weight: 231.15264
• EINECS: -0
• Mol File: 70398-89-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-BroMo-4-isopropylsulfanyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BroMo-4-isopropylsulfanyl-benzene(70398-89-9)
• EPA Substance Registry System: 1-BroMo-4-isopropylsulfanyl-benzene(70398-89-9)

Safety Data

• Hazardous Substances Data: 70398-89-9(Hazardous Substances Data)

Usage

Class

Aromatic compounds, benzene and substituted derivatives

Molecular weight

241.175 g/mol

Physical state

Clear liquid at room temperature

Applications

a. Synthesis of pharmaceuticals
b. Synthesis of agrochemicals
c. Production of dyes and pigments
d. Manufacturing of organic compounds
e. Intermediate in chemical processes

Safety

Handle with care due to potentially hazardous nature

Upstream product

• 106-37-6 1.4-dibromobenzene 
• 20607-43-6 sodium isopropanethiolate 
• 106-53-6 para-bromobenzenethiol 
• 75-26-3 isopropyl bromide 
• 75-29-6 isopropyl chloride 

Downstream Products

• 70399-02-9 1-bromo-4-(1-methylethylsulfonyl)benzene 
• 13205-50-0 4-(isopropylthio)benzoic acid 
• 14905-81-8 1-(isopropylthio)-4-methylbenzene 
• 128102-48-7 5-Methyl-2-(isopropylthio)benzoic acid 
• 380427-38-3 [4-(propan-2-ylsulfanyl)phenyl]boronic acid 
• 1186233-80-6 3β-(4-isopropylthiophenyl)tropane-2β-carboxylic acid methyl ester 
• 1368724-01-9 C₁₃H₁₅N₃OS 
• 1415309-93-1 C₁₅H₂₃BO₂S 
• 1129287-54-2 1-bromo-4-(isopropylsulfinyl)benzene 
• 65251-10-7 ethyl 2-((4-bromophenyl)thio)acetate 
• 3226-41-3 4-bromobenzenediazonium tetrafluoroborate 
• 850567-98-5 4-(isopropylsulfonyl)phenylboronic acid 

Relevant articles and documents

Preparation method of 4-isopropylsulfonylphenylboronic acid

The invention discloses a preparation method of 4-isopropylsulfonylphenylboronic acid, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps of: taking 4-bromothiophenol and halogenated isopropane as the raw materials, and acquiring 1-bromo-4-isopropyl thiobenzene under the action of potassium carbonate; performing oxidizing with hydrogen peroxide in the presence of a catalyst to obtain 1-bromo-4-isopropylsulfonylbenzene, and finally, carrying out Grignard exchange/borate reaction with a Grignard reagent to obtain 4-isopropylsulfonylphenylboronic acid. The method has the advantages of high yield, simple process, cheap and easily available raw materials, green chemistry, and 6 times of application of the catalyst, and has an industrial amplification prospect.

Regenerable Thiophenolic Radical-Trapping Antioxidants

Diphenyl disulfides carrying alkyltelluro groups in the o-, m-, and p-positions were prepared using ortho-lithiation and lithium halogen exchange reactions. The novel antioxidants showed only minimal inhibitory effect on the azo-initiated peroxidation of linoleic acid in chlorobenzene until reduced to the corresponding thiophenols by tris(2-carboxyethyl)phosphine (TCEP). The best in situ generated thiophenol (from 7c) under these conditions quenched peroxyl radicals more efficiently than α-tocopherol with an almost 3-fold increase in inhibition time.

GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.