70399-01-8 Usage
General Description
1-Bromo-3-(isopropylsulfonyl)benzene, also known as 2-bromo-4-(propan-2-ylsulfonyl)phenyl bromide, is an organic compound with the molecular formula C9H11BrO2S. It is a benzene derivative with two substituents - a bromine atom and an isopropylsulfonyl group. 1-BroMo-3-(isopropylsulfonyl)benzene is commonly used as a starting material in the synthesis of biologically active molecules and pharmaceuticals. Additionally, it can also be used in organic reactions, such as Suzuki-Miyaura cross-coupling reactions, to form carbon-carbon bonds. 1-Bromo-3-(isopropylsulfonyl)benzene is a colorless to light yellow liquid with a slightly sweet aromatic odor, and it should be handled and stored in a well-ventilated area due to its potential health hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 70399-01-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,3,9 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 70399-01:
(7*7)+(6*0)+(5*3)+(4*9)+(3*9)+(2*0)+(1*1)=128
128 % 10 = 8
So 70399-01-8 is a valid CAS Registry Number.
70399-01-8Relevant articles and documents
Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**
Sutherland, Mathew,Li, Alice,Kaghad, Anissa,Panagopoulos, Dimitrios,Li, Fengling,Szewczyk, Magdalena,Smil, David,Scholten, Cora,Bouché, Léa,Stellfeld, Timo,Arrowsmith, Cheryl H.,Barsyte, Dalia,Vedadi, Masoud,Hartung, Ingo V.,Steuber, Holger,Britton, Robert,Santhakumar, Vijayaratnam
supporting information, p. 1116 - 1125 (2021/03/08)
Protein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers has stimulated interest in the discovery of inhibitors as biological tools and, potentially, therapeutics. Although several PRMT4 inhibitors have been reported, most display poor selectivity against other members of the PRMT family of methyl transferases. Herein, we report the structure-based design of a new class of alanine-containing 3-arylindoles as potent and selective PRMT4 inhibitors, and describe key structure–activity relationships for this class of compounds.
