704-03-0

Basic information

• Product Name: 5-Fluoro-2-Methoxybenzoyl chloride
• Synonyms: 5-Fluoro-2-Methoxybenzoyl chloride
• CAS NO: 704-03-0
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.5834432
• Mol File: 704-03-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 123-124 °C(Press: 11 Torr)
• Appearance: /
• Density: 1.309±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-Fluoro-2-Methoxybenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-Methoxybenzoyl chloride(704-03-0)
• EPA Substance Registry System: 5-Fluoro-2-Methoxybenzoyl chloride(704-03-0)

Safety Data

• Hazardous Substances Data: 704-03-0(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-Methoxybenzoyl chloride is a chemical compound with the formula C8H6ClFO2 that is commonly used in organic synthesis. It is a derivative of benzoyl chloride with the addition of a fluorine atom at the 5 position and a methoxy group at the 2 position of the benzene ring. 5-Fluoro-2-Methoxybenzoyl chloride is a reactive and versatile reagent that is often used in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its ability to undergo acylation reactions with a variety of nucleophiles, and it is also used as a building block in the synthesis of a range of organic compounds. Additionally, it is a useful intermediate in the production of complex organic molecules and is commonly used in research and development laboratories.

Upstream product

• 394-04-7 5-fluoro-2-methoxybenzoic acid 

Downstream Products

• 1427-22-1 5-fluoro-2-methoxy-N-(3-morpholin-4-yl-propyl)-benzamide 
• 61629-63-8 β-{4-[2-(5-fluoro-2-methoxybenzamido)-ethyl]-phenyl}-propionic acid 
• 5710-39-4 5-Fluor-2-methoxy-benzoesaeure-<2-dimethylamino-aethylester> 
• 5710-40-7 5-Fluor-2-methoxy-benzoesaeure-<2-diisopropylamino-aethylester> 
• 5710-42-9 5-Fluor-2-methoxy-benzoesaeure-<3-dimethylamino-propylester> 
• 5710-43-0 5-Fluor-2-methoxy-benzoesaeure-<3-diaethylamino-propylester> 
• 5710-41-8 5-Fluor-2-methoxy-benzoesaeure-<2-dibutylamino-aethylester> 
• 5749-35-9 5-Fluor-2-methoxy-benzoesaeure-<3-dibutylamino-propylester> 
• 1146161-62-7 1-tert-butyl 2-methyl (2R,4S)-4-(2-(5-fluoro-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1,2-dicarboxylate 
• 1146161-64-9 4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol 
• 1262849-62-6 (R)-2-(4-(3-(dimethylamino)pyrrolidin-1-yl)quinazolin-2-yl)-4-fluorophenol 
• 1311204-99-5 C₁₅H₁₁FN₂O₂ 
• 1146160-83-9 C₁₅H₁₀ClFN₂O 
• 1146161-90-1 2-(4-chloroquinazolin-2-yl)-4-fluorophenol 

Relevant articles and documents

CYCLOALKYLIDENE CARBOXYLIC ACIDS AND DERIVATIVES AS BTK INHIBITORS

The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).

PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER

This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK). The invention also contemplates the use of t

Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III)

The marine natural product, marinopyrrole A (1), was previously shown to have significant antibiotic activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Although compound (1) exhibits a significant reduction in MRSA activity in the presence of human serum, we have identified key modifications that partially restore activity. We previously reported our discovery of a chloro-derivative of marinopyrrole A (1a) featuring a 2-4 fold improved minimum inhibitory concentration (MIC) against MRSA, significantly less susceptibility to serum inhibition and rapid and concentration-dependent killing of MRSA. Here, we report a novel fluoro-derivative of marinopyrrole A (1e) showing an improved profile of potency, less susceptibility to serum inhibition, as well as rapid and concentration-dependent killing of MRSA.