704-05-2

Basic information

• Product Name: 4-FLUORO-2-NITRO-N-METHYLANILINE
• Synonyms: BUTTPARK 45\09-95;4-FLUORO-2-NITRO-N-METHYLANILINE;N-METHYL-4-FLUORO-2-NITROANILINE;4-Fluoro-N-Methyl-2-nitroaniline
• CAS NO: 704-05-2
• Molecular Formula: C₇H₇FN₂O₂
• Molecular Weight: 170.14
• Mol File: 704-05-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 76 °C(Solv: hexane (110-54-3))
• Boiling Point: 275.8±30.0 °C(Predicted)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• PKA: -0.80±0.25(Predicted)
• CAS DataBase Reference: 4-FLUORO-2-NITRO-N-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-NITRO-N-METHYLANILINE(704-05-2)
• EPA Substance Registry System: 4-FLUORO-2-NITRO-N-METHYLANILINE(704-05-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 704-05-2(Hazardous Substances Data)

Usage

General Description

4-Fluoro-2-nitro-N-methylaniline is a chemical compound with the molecular formula C7H7FN2O2. It is an organic compound that contains a fluorine and a nitro group attached to a benzene ring, along with a methylamine group. It is used in the synthesis of various pharmaceuticals, dyes, and polymers. The chemical is also used as an intermediate for the production of agricultural products and insecticides. It is important to handle this compound carefully as it is toxic and may cause skin and eye irritation upon direct contact.

Upstream product

• 128691-91-8 2,2,2-trifluoro-N-(4-fluoro-2-nitrophenyl)acetamide 
• 77-78-1 dimethyl sulfate 
• 655-56-1 N-methyl-N-(4-fluorophenyl)nitramine 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 74-89-5 methylamine 
• 364-78-3 2-nitro-4-fluoroaniline 
• 446-35-5 2,4-Difluoronitrobenzene 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 401567-10-0 4-fluoro-N₁-methylbenzene-1,2-diamine 
• 401567-11-1 5-fluoro-1-methyl-1H-benzimidazol-2-ol 
• 401567-11-1 5-fluoro-1-methyl-1,3-dihydro-2H-benzo[d]imidazole-2-one 
• 401567-12-2 2-chloro-5-fluoro-1-methyl-1H-benzimidazole 
• 1365271-95-9 5-fluoro-1-methyl-1H-benzo[d]imidazole 

Relevant articles and documents

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

TRANSGLUTAMINASE 2 (TG2) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit transglutaminase 2 (TG2). Also described herein are methods for using such TG2 inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from TG2 inhibition.

COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS

The present invention relates to new medicament combinations which contain in addition to one or more PDE4-inhibitors (1) at least one EP4 receptor antagonist (2), as well as the use thereof for the treatment of preferably respiratory complaints such as particularly COPD, chronic sinusitis and asthma. The invention relates in particular to those medicament combinations which contain at least one EP4 receptor antagonist (2), in addition to one or more, preferably one, PDE4 inhibitor of general formula 1 wherein X is SO or SO2, but preferably SO, and wherein R3 denotes an optionally substituted, mono- or bicyclic, unsaturated, partly saturated or saturated heterocyclic group or an optionally substituted, mono- or bicyclic heteroaryland wherein R1 and R2 have the meanings given in claim 1, the preparation thereof and the use thereof for the treatment of respiratory complaints.