704-36-9

Basic information

• Product Name: Ethanone, 2,2-difluoro-1-(4-methylphenyl)- (9CI)
• Synonyms: Ethanone, 2,2-difluoro-1-(4-methylphenyl)- (9CI);2,2-difluoro-1-(4-methylphenyl)ethanone
• CAS NO: 704-36-9
• Molecular Formula: C₉H₈F₂O
• Molecular Weight: 170.1560264
• Product Categories: ACETYLHALIDE
• Mol File: 704-36-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 223.3°C at 760 mmHg
• Flash Point: 84.1°C
• Appearance: /
• Density: 1.145g/cm³
• Vapor Pressure: 0.0972mmHg at 25°C
• Refractive Index: 1.469
• CAS DataBase Reference: Ethanone, 2,2-difluoro-1-(4-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-difluoro-1-(4-methylphenyl)- (9CI)(704-36-9)
• EPA Substance Registry System: Ethanone, 2,2-difluoro-1-(4-methylphenyl)- (9CI)(704-36-9)

Safety Data

• Hazardous Substances Data: 704-36-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8F2O/c1-6-2-4-7(5-3-6)8(12)9(10)11/h2-5,9H,1H3

Upstream product

• 686-11-3 N,N-diethyl-2,2-difluoroacetamide 
• 2417-95-0 p-tolyllithium 
• 173974-83-9 Propyl-[1-p-tolyl-eth-(E)-ylidene]-amine 
• 413597-89-4 ((2,2-difluoro-1-(p-tolyl)vinyl)oxy)trimethylsilane 
• 1044589-10-7 (2,2-difluoro-1-p-tolyl-ethylidene)(4-fluoro-phenyl)amine 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 1337572-01-6 C₁₈H₂₂F₂O₂SSi 
• 454-31-9 ethyl difluoroacetate 
• 106-38-7 para-bromotoluene 
• 50562-10-2 2,2-difluoro-1-(4-methylphenyl)ethanol 
• 122-00-9 para-methylacetophenone 
• 720-94-5 4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione 
• 13422-78-1 3-oxo-3-p-toluoylpropanoic acid 
• 142492-01-1 2,2-difluoro-N-methoxy-N-methylacetamide 

Downstream Products

• 50562-10-2 2,2-difluoro-1-(4-methylphenyl)ethanol 
• 413598-37-5 (2-fluoro-1-p-tolyl-vinyloxy)-trimethyl-silane 
• 37032-34-1 2-fluoro-1-(4-methylphenyl)ethanone 
• 704-33-6 1-(3,3-difluoroprop-1-en-2-yl)-4-methylbenzene 
• 50562-11-3 Toluene-4-sulfonic acid 2,2-difluoro-1-p-tolyl-ethyl ester 
• 50561-97-2 1-(2,2-difluoroethyl)-4-methylbenzene 
• 1577233-03-4 2,2-difluoro-2-(4-methoxyphenyl)-1-(p-tolyl)ethanone 
• 69843-09-0 1-methyl-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene 

Relevant articles and documents

A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones

Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre

Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes

The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat

Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines

Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Br?nsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.