7040-52-0

Basic information

• Product Name: Cyclohexyl methyl methylphosphonate
• Synonyms: P-Methylphosphonic acid cyclohexyl methyl ester
• CAS NO: 7040-52-0
• Molecular Formula: C₈H₁₇O₃P
• Molecular Weight: 192.19
• Mol File: 7040-52-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 260℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.0201mmHg at 25°C
• Refractive Index: 1.433
• Water Solubility: It is sparingly soluble in both organic solvents and water, but become more soluble in water when neutralized to phosphonates at
• CAS DataBase Reference: Cyclohexyl methyl methylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexyl methyl methylphosphonate(7040-52-0)
• EPA Substance Registry System: Cyclohexyl methyl methylphosphonate(7040-52-0)

Safety Data

• Hazardous Substances Data: 7040-52-0(Hazardous Substances Data)

Usage

Uses

Cyclohexyl methyl methylphosphonate or phosphonic acid is used as a micro-nano electronic materials have extended self-assembled monolayers (SAMs) beyond conventional gold/thiol systems. To expand the choice of the substrate used for the preparation of SAMs, the chemical functionalities in film-forming molecules can be altered by introducing phosphate or phosphonate groups. Such polar acidic molecules are capable of interacting with diverse metal-oxide surfaces (e.g., Al2O3, Ta2O5, NbO5, ZrO2 and TiO2) and form films with a similar degree of ordering as for alkyl thiol SAMs on gold.

InChI:InChI=1/C8H17O3P/c1-10-12(2,9)11-8-6-4-3-5-7-8/h8H,3-7H2,1-2H3

Upstream product

• 1066-52-0 methyl methylphosphonochloridate 
• 22096-22-6 sodium cyclohexanolate 
• 67-56-1 methanol 
• 329-99-7 GF 
• 175352-88-2 Phosphorous acid cyclohexyl ester dimethyl ester 
• 74-88-4 methyl iodide 
• 1932-60-1 methylphosphonic acid monocyclohexyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 
• 676-97-1 methylphosphonic acid dichloroanhydride 
• 108-93-0 cyclohexanol 

Downstream Products

• 1932-60-1 methylphosphonic acid monocyclohexyl ester 

Relevant articles and documents

Synthesis of alkyl methylphosphonic acid esters

A synthesis and isolation scheme is described for producing mono alkyl esters of methylphosphonic acid based upon stoichiometric addition of alcohol to methylphosphonic dichloride. Solvent extraction is applied to the reaction mixture to separate the mono

Synthesis of alkyl- and arylphosphonic acid monoesters by direct esterification of dibasic phosphonic acids in the presence of an arsonic acid catalyst

Partial hydrolysis of a diester, hydrolysis of the monochloro monoester, or alcoholysis of a phosphonic acid anhydride generally is used to prepare monoesters of alkyl- and arylphosphonic acids. Limited cases have been reported for the esterification of a dibasic phosphonic acid to yield the monoester, and none of these methods are as simple as the analogous method for preparing carboxylic acid esters, in which the carboxylic acid is esterified with an alcohol in the presence of an acid catalyst. Described is a method for preparing monoesters of alkyl- and arylphosphonic acids by direct esterification with an alcohol in the presence of a catalytic amount of phenylarsonic acid. The water formed during the reaction is removed azeotropically. For example, methylphosphonic acid was esterified in good yield to give its isopropyl, butyl, cyclohexyl, bornyl, and octadecyl monoesters. Similarly prepared are the ethyl, butyl, hexyl, and 2-(ethylthio)ethyl monoesters of phenylphosphonic acid, as well as 2-isopropoxyethyl hydrogen ethylphosphonate and 2-methoxyethyl hydrogen benzylphosphonate.

Inhibition of plasma cholinesterase by O-alkylfluorophosphonates

Inhibition of plasma cholinesterase by three methylfluorophosphonates (MFF), sarin, soman and cyclosin, and by the products of their hydrolysis and alcoholysis was examined. Inhibition by phosphonic acids and by methyl esters derived from MFF was purely competitive while that by MFF was irreversible. The rate of phosphorylation of cholinesterase by MFF differs, depending on the structure of the alkoxy group in the MFF and decreases in the sequence soman-sarin-cyclosin. The affinity values of MFF, phosphonic acids and methyl esters of phosphonic acid for cholinesterase are comparable. The in vitro kinetic parameters suggest that plasma cholinesterase might act as a natural detoxicating agent in cases of poisoning with the above inhibitors of acetylcholinesterase.