70404-28-3Relevant articles and documents
Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors
Shelke, Rupesh U.,Degani, Mariam S.,Raju, Archana,Ray, Mukti Kanta,Rajan, Mysore G. R.
, p. 602 - 613 (2016/08/28)
Fragment-based drug design was used to identify Mycobacterium tuberculosis (Mtb) dihydrofolate reductase (DHFR) inhibitors. Screening of ligands against the Mtb DHFR enzyme resulted in the identification of multiple fragment hits with IC50 values in the range of 38–90 μM versus Mtb DHFR and minimum inhibitory concentration (MIC) values in the range of 31.5–125 μg/mL. These fragment scaffolds would be useful for anti-tubercular drug design.
Microwave-assisted synthesis of 8-mercapto-3-methyl-7-alkyl xanthines - An improved method
Zhang, Lei,Zhang, Y. John
, p. 775 - 778 (2007/10/03)
A microwave-assisted synthetic method to prepare novel 8-mercapto-3-methyl- 7-alkyl xanthine compounds is reported. Compared to conventional synthetic route, the new method significantly shortened synthetic steps and reaction time.
Purine Studies. XXIII. Conformational Aspects of N-(6-Amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-formamides and Related N-Benzyl Derivatives
Fenn, David M.,Lister, John H.
, p. 1611 - 1617 (2007/10/02)
The occurrence of 'Z' and 'E' conformers in 5-formamidouracil derivatives has been investigated by 1H n.m.r. and the effect of the nature and size of the substituents on the isomer ratio studied.Also considered was the relative steric competition between
