70404-40-9Relevant articles and documents
7,8-substituted-3-methylxanthine compounds as well as preparation method and application thereof
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Paragraph 0040; 0041; 0046; 0047, (2018/09/08)
The invention discloses 7,8-substituted-3-methylxanthine compounds as well as a preparation method and an application thereof. The compounds have the structural formula (I) shown in the description, wherein R is aliphatic hydrocarbon, an aromatic ring, an acyl-containing group, a hydroxyl-containing group or a sulfhydryl-containing group; R1 is C1-4 alkyl, halogen substituted C1-4 alkyl, C1-4 alkoxy, halogen, a cyano group, nitryl, acetyl, benzyl, benzyloxy, substituted or unsubstituted C1-4 alkylbenzene, a substituted or unsubstituted amino group, substituted guanidyl, a substituted or unsubstituted phosphate group, a substituted or unsubstituted sulfonic group, a substituted or unsubstituted long-chain fatty alkane or substituted or unsubstituted long-chain fatty amine. The compounds have good inhibition effects on PDE8 (phosphodiesterase type 8), PDE8 is also a potential target of the alzheimer's disease, vascular dementia and diabetes, the compounds take PDE8 as the target, and a drug prepared from the compounds has a better curative effect on alzheimer's disease, vascular dementia and diabetes as well.
