70407-20-4

Basic information

• Product Name: territrem B
• Synonyms: territrem B;(4aR)-4a,6,6a,12,12a,12b-Hexahydro-4aβ,12aβ-dihydroxy-4,4,6aα,12bα-tetramethyl-9-(3,4,5-trimethoxyphenyl)-4H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-1,11(5H)-dione;TERRITREM B(RG)
• CAS NO: 70407-20-4
• Molecular Formula: C29H34O9
• Molecular Weight: 526.579
• Mol File: 70407-20-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 200～203℃
• Boiling Point: 693°C at 760 mmHg
• Flash Point: 226.5°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 3.68E-20mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: territrem B(CAS DataBase Reference)
• NIST Chemistry Reference: territrem B(70407-20-4)
• EPA Substance Registry System: territrem B(70407-20-4)

Safety Data

• Hazardous Substances Data: 70407-20-4(Hazardous Substances Data)

Usage

Description

Different sources of media describe the Description of 70407-20-4 differently. You can refer to the following data:
1. Territrem B (TRB) is a fungal metabolite isolated from Aspergillus terreus shown previously to be a potent and irreversible inhibitor of acetylcholinesterase (AChE).
2. Territrem B is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 19 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg, and has an LD50 value of 9.06 mg/kg.

Uses

Different sources of media describe the Uses of 70407-20-4 differently. You can refer to the following data:
1. Territrem B is a potent and irreversible inhibitor of acetylcholinesterase.
2. Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.

Biological Activity

Territrem B is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 19 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg, and has an LD50 value of 9.06 mg/kg.

InChI:InChI=1/C29H34O9/c1-25(2)9-8-22(30)27(4)28(25,32)11-10-26(3)29(27,33)15-17-19(38-26)14-18(37-24(17)31)16-12-20(34-5)23(36-7)21(13-16)35-6/h8-9,12-14,32-33H,10-11,15H2,1-7H3/t26-,27+,28-,29-/m1/s1