70414-49-2

Basic information

• Product Name: 2,2-Dimethyl-1-(Morpholin-4-Yl)Propan-1-One
• Synonyms: 2,2-Dimethyl-1-(Morpholin-4-Yl)Propan-1-One;2,2-Dimethyl-1-(Morpholin-4-Yl)Propan-1-One(WXC04423)
• CAS NO: 70414-49-2
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.23678
• Mol File: 70414-49-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-Dimethyl-1-(Morpholin-4-Yl)Propan-1-One(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-1-(Morpholin-4-Yl)Propan-1-One(70414-49-2)
• EPA Substance Registry System: 2,2-Dimethyl-1-(Morpholin-4-Yl)Propan-1-One(70414-49-2)

Safety Data

• Hazardous Substances Data: 70414-49-2(Hazardous Substances Data)

Usage

General Description

2,2-Dimethyl-1-(Morpholin-4-Yl)Propan-1-One, also known as DMP-4, is a chemical compound with the molecular formula C10H19NO2. It is commonly used as a reagent in organic synthesis and pharmaceutical research. DMP-4 is a white solid with a mild, pleasant odor, and it is soluble in most organic solvents. This chemical is known for its use as a reagent for the synthesis of pharmaceutical compounds and as an intermediate in the production of other chemicals. It is important to handle this chemical with care, as it may have potential health hazards, and proper safety measures should be taken when working with it.

Upstream product

• 22502-84-7 4-(1-t-butylethenyl)morpholine 
• 15159-40-7 4-morpholinocarbonyl chloride 
• 677-22-5 tert-butylmagnesium chloride 
• 110-91-8 morpholine 
• 3282-30-2 pivaloyl chloride 
• 75-98-9 Trimethylacetic acid 
• 55561-02-9 thiopivalic acid 
• 630-19-3 pivalaldehyde 
• 201230-82-2 carbon monoxide 
• 558-17-8 tert-Butyl iodide 

Downstream Products

• 598-98-1 Methyl pivalate 
• 155397-12-9 2,2-dimethyl-1-(dimethyl(phenyl)silyl)propan-1-one 

Relevant articles and documents

Tandem Photoredox Catalysis: Enabling Carbonylative Amidation of Aryl and Alkylhalides

We report a new visible-light-mediated carbonylative amidation of aryl, heteroaryl, and alkyl halides. A tandem catalytic cycle of [Ir(ppy)2(dtb-bpy)]+ generates a potent iridium photoreductant through a second catalytic cycle in the presence of DIPEA, which productively engages aryl bromides, iodides, and even chlorides as well as primary, secondary, and tertiary alkyl iodides. The versatile in situ generated catalyst is compatible with aliphatic and aromatic amines, shows high functional-group tolerance, and enables the late-stage amidation of complex natural products.

Rhodium-Catalyzed oxidative amidation of sterically hindered aldehydes and alcohols

A rhodium-catalyzed oxidative amidation reaction has been developed with sterically hindered aldehydes and alcohols for the synthesis of amides containing a quaternary carbon at the α position. A variety of amine nucleophiles, both aliphatic and aromatic, are employed and afford the corresponding amides in good to excellent yields. Finally, mechanistic studies are performed to gain insight into both catalytic cycles.

Samarium-mediated mild and facile method for the synthesis of amides

Samarium-mediated facile method for the formation of amide bonds by the reaction of acyl chlorides and amines is described. The reaction afforded high yields of the desired amides under mild and neutral conditions.