70416-53-4

Basic information

• Product Name: 5-FORNYL-3-PYRIDINECARBONITRILE
• Synonyms: 5-FORNYL-3-PYRIDINECARBONITRILE;5-FORMYL-3-PYRIDINECARBONITRILE;5-ForMyl-nicotinonitrile;3-Cyano-5-formylpyridine;5-Cyanopyridine-3-carboxaldehyde;5-formylpyridine-3-carbonitrile
• CAS NO: 70416-53-4
• Molecular Formula: C7H4N2O
• Molecular Weight: 132.12
• Mol File: 70416-53-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 229.342 °C at 760 mmHg
• Flash Point: 92.503 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 0.07mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.01±0.20(Predicted)
• CAS DataBase Reference: 5-FORNYL-3-PYRIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FORNYL-3-PYRIDINECARBONITRILE(70416-53-4)
• EPA Substance Registry System: 5-FORNYL-3-PYRIDINECARBONITRILE(70416-53-4)

Safety Data

• Hazardous Substances Data: 70416-53-4(Hazardous Substances Data)

Usage

General Description

5-Fornyl-3-pyridinecarbonitrile is a chemical compound with the molecular formula C7H4N2O and a molecular weight of 132.12 g/mol. It is a heterocyclic compound containing a pyridine ring and a nitrile group, and it is commonly used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals. This chemical is considered to be stable under normal conditions and is not flammable, but it should be stored in a cool, dry place away from heat, sparks, and open flames. 5-Fornyl-3-pyridinecarbonitrile is also known by other names such as 5-formylpyridine-3-carbonitrile and 5-formyl-3-cyanopyridine, and its CAS number is 3197-52-0.

InChI:InChI=1/C7H4N2O/c8-2-6-1-7(5-10)4-9-3-6/h1,3-5H

Upstream product

• 135124-71-9 5-(hydroxymethyl)pyridine-3-carbonitrile 
• 70416-52-3 5-[1,3]dioxolan-2-yl-nicotinonitrile 
• 113118-81-3 5-bromopyridine-3-carbaldehyde 
• 35590-37-5 5-bromopyridine-3-carbonitrile 
• 100949-02-8 5-vinylnicotinonitrile 

Downstream Products

• 135124-71-9 5-(hydroxymethyl)pyridine-3-carbonitrile 
• 562074-59-3 5-(chloromethyl)nicotinonitrile hydrochloride 

Relevant articles and documents

PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION

The compounds of Formula Ib, Formula Ia, and Formula I are described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The process of preparation of the compounds of Formula Ib, Formula Ia, and Formula I is also described. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are 2-(benzyloxy)pyrimidine derivatives that are inhibitors of PD-1/PD-L1 activation.

ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1)

The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.