70419-10-2

Basic information

• Product Name: (S)-2-AMINO-6-METHYLHEPTANE
• Synonyms: (S)-2-AMINO-6-METHYLHEPTANE;(S)-1,5-DIMETHYLHEXYLAMINE;(2S)-6-Methyl-heptylamine;(S)-2-Amino-6-methylheptane(e.e.);(S)-2-Amino-6-methylheptane,95%,98% ee;(2S)-6-methylheptan-2-amine
• CAS NO: 70419-10-2
• Molecular Formula: C7H17N
• Molecular Weight: 115.22
• EINECS: 274-598-9
• Mol File: 70419-10-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 11.43°C (estimate)
• Boiling Point: 169.36°C (estimate)
• Flash Point: 48.9 °C
• Appearance: /
• Density: 0.7670
• Refractive Index: 1.4148 (estimate)
• CAS DataBase Reference: (S)-2-AMINO-6-METHYLHEPTANE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-AMINO-6-METHYLHEPTANE(70419-10-2)
• EPA Substance Registry System: (S)-2-AMINO-6-METHYLHEPTANE(70419-10-2)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R10:Flammable.; R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S16:Keep away from sources of ignition - No smoking.; S26:In case of contact with eyes, rinse immediately with plenty of
• Hazardous Substances Data: 70419-10-2(Hazardous Substances Data)

Usage

Chemical Properties

brown liquid

Upstream product

• 540-69-2 ammonium formate 
• 928-68-7 6-methylheptan-2-one 
• 70419-11-3 (R)-6-methylheptan-2-amine 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 143-07-7 lauric acid 
• 543-82-8 1,5-dimethylhexylamine 
• 3852-09-3 methyl 3-methoxypropionate 
• 1384127-07-4 N-octanoyl dimethyl glycine trifluoroethyl ester 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 1100753-75-0 N-octanoylglycine 2,2,2-trifluoroethyl ester 
• 1222802-05-2 N-octanoyl-L-alanine 2,2,2-trifluoroethyl ester 

Downstream Products

• 30121-80-3 4-{[(E)-1,5-Dimethyl-hexylimino]-methyl}-2-ethoxy-phenol 
• 30121-85-8 (1,5-Dimethyl-hexyl)-[2-[1-phenyl-meth-(E)-ylidene]-oct-(E)-ylidene]-amine 
• 30121-81-4 (1,5-Dimethyl-hexyl)-[2-phenyl-eth-(E)-ylidene]-amine 
• 30121-74-5 (1,5-Dimethyl-hexyl)-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine 
• 30121-77-8 N-(4-{[(E)-1,5-Dimethyl-hexylimino]-methyl}-phenyl)-acetamide 
• 30121-68-7 (1,5-Dimethyl-hexyl)-[1-phenyl-meth-(E)-ylidene]-amine 
• 30121-69-8 4-{[(E)-1,5-Dimethyl-hexylimino]-methyl}-phenol 
• 30121-71-2 (1,5-Dimethyl-hexyl)-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine 
• 30121-72-3 2-{[(E)-1,5-Dimethyl-hexylimino]-methyl}-phenol 
• 30121-78-9 4-{[(E)-1,5-Dimethyl-hexylimino]-methyl}-2-methoxy-phenol 
• 30121-75-6 [1-(2,5-Dimethoxy-phenyl)-meth-(E)-ylidene]-(1,5-dimethyl-hexyl)-amine 
• 30121-84-7 (1,5-Dimethyl-hexyl)-[2-[1-phenyl-meth-(E)-ylidene]-hept-(E)-ylidene]-amine 
• 30121-82-5 (1,5-Dimethyl-hexyl)-[(E)-3-phenyl-prop-2-en-(E)-ylidene]-amine 
• 30121-70-1 (4-{[(E)-1,5-Dimethyl-hexylimino]-methyl}-phenyl)-dimethyl-amine 

Relevant articles and documents

Ruthenium Catalyzed Direct Asymmetric Reductive Amination of Simple Aliphatic Ketones Using Ammonium Iodide and Hydrogen

The direct conversion of ketones into chiral primary amines is a key transformation in chemistry. Here, we present a ruthenium catalyzed asymmetric reductive amination (ARA) of purely aliphatic ketones with good yields and moderate enantioselectivity: up to 99 percent yield and 74 percent ee. The strategy involves [Ru(PPh3)3H(CO)Cl] in combination with the ligand (S,S)-f-binaphane as the catalyst, NH4I as the amine source and H2 as the reductant. This is a straightforward and user-friendly process to access industrially relevant chiral aliphatic primary amines. Although the enantioselectivity with this approach is only moderate, to the extent of our knowledge, the maximum ee of 74 percent achieved with this system is the highest reported till now apart from enzyme catalysis for the direct transformation of ketones into chiral aliphatic primary amines.

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Asymmetric catalysis of the carbonyl-amine condensation: Kinetic resolution of primary amines

A Br?nsted acid catalyzed kinetic resolution of primary amines is described that is based on the condensation between an amine and a carbonyl compound. 1,3-Diketones react with racemic α-branched amines to furnish the corresponding enantioenriched enaminone and recovered starting material. Good to excellent enantioselectivity was observed with both aromatic and aliphatic primary amines. This process represents the first small-molecule catalyzed kinetic resolution of aliphatic amines.