70437-05-7Relevant articles and documents
A Garratt-Braverman cyclization route towards the synthesis of phenanthridine derivatives and their DNA-binding studies
Mandal, Arundhoti,Bhattacharya, Prabuddha,Das, Amit K.,Basak, Amit
, p. 1975 - 1987 (2019/02/24)
Garratt-Braverman cyclization has been employed to synthesize a series of dihydroisofuran fused phenanthridine derivatives. The established protocol proposes a simpler synthetic alternative to have access to these therapeutically relevant cytotoxic scaffo
Acyclic diaminocarbenes: Simple, versatile ligands for cross-coupling reactions
Dhudshia, Bhartesh,Thadani, Avinash N.
, p. 668 - 670 (2008/02/10)
Acyclic diaminocarbenes are found to be useful ligands for palladium catalyzed Suzuki-Miyaura, Sonogashira and Heck cross-coupling reactions of aryl/alkenyl bromides and chlorides. The Royal Society of Chemistry 2006.
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: Synthesis and structure-activity relationships
Glase, Shelly A.,Akunne, Hyacinth C.,Heffner, Thomas G.,Jaen, Juan C.,MacKenzie, Robert G.,Meltzer, Leonard T.,Pugsley, Thomas A.,Smith, Sarah J.,Wise, Lawrence D.
, p. 3179 - 3187 (2007/10/03)
A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6- tetrahydropyridines with dopaminergic activity is described. The structure- activity relationships of this series were studied by synthesis of analogs and evaluation of their affinities for the dopamine (DA) D2 receptor and inhibition of locomotor activity (LMA) in rodents. The basic amine, alkyne chain length, and aryl groups were varied. Compounds having a 4-phenyl- 1,2,3,6-tetrahydropyridine and an aryl group with hydrogen-bonding substituents separated by a butynyl chain were found to have the most potent dopaminergic activity. Several compounds that were found to have exceptional in vivo activity in LMA inhibition in rodents were evaluated for additional pharmacological activity including binding affinities for other DA receptor subtypes as well as effects on brain DA synthesis, DA neuronal firing, and conditioned avoidance responding in squirrel monkeys.
