7044-99-7

Basic information

• Product Name: 4,5-bis(4-methoxyphenyl)-2-phenyl-1H-imidazole
• Synonyms: 1H-imidazole, 4,5-bis(4-methoxyphenyl)-2-phenyl-; 4,5-Bis(4-methoxyphenyl)-2-phenyl-1H-imidazole
• CAS NO: 7044-99-7
• Molecular Formula: C₂₃H₂₀N₂O₂
• Molecular Weight: 356.4171
• Mol File: 7044-99-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 563.4°C at 760 mmHg
• Flash Point: 197°C
• Density: 1.169g/cm³
• Vapor Pressure: 3.89E-12mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 4,5-bis(4-methoxyphenyl)-2-phenyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-bis(4-methoxyphenyl)-2-phenyl-1H-imidazole(7044-99-7)
• EPA Substance Registry System: 4,5-bis(4-methoxyphenyl)-2-phenyl-1H-imidazole(7044-99-7)

Safety Data

• Hazardous Substances Data: 7044-99-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 119-52-8 4,4'-dimethoxybenzoin 
• 126177-56-8 1-benzyl-4,5-dibromo-2-phenyl-1H-imidazole 
• 1448032-53-8 1-benzyl-4,5-di(4-methoxyphenyl)-2-phenyl-1H-imidazole 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 142217-42-3 1-(7-Ethoxy-carbonylheptyl)-4,5-bis-(4-methoxyphenyl)-2-phenylimidazole 

Relevant articles and documents

TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions

In the process of drug discovery and development, an efficient and expedient synthetic method for imidazole-based small molecules from commercially available and cheap starting materials has great significance. Herein, we developed a TMSOTf-catalyzed synthesis of trisubstituted imidazoles through the reaction of 1,2-diketones and aldehydes using hexamethyldisilazane as a nitrogen source under microwave heating and solvent-free conditions. The chemical structures of representative trisubstituted imidazoles were confirmed using X-ray single-crystal diffraction analysis. This synthetic method has several advantages including the involvement of mild Lewis acid, being metal- and additive-free, wide substrate scope with good to excellent yields and short reaction time. Furthermore, we demonstrate the application of the methodology in the synthesis of biologically active imidazole-based drugs.

One-Pot Three-Component Synthesis of 2,4,5-Triaryl-1 H -imidazoles in the Presence of a Molecular Sieve Supported Titanium Catalyst under Mild Basic Conditions

A series of 2,4,5-trisubstituted-imidazoles has been synthesized with good to excellent yields by the one-pot condensation reaction of 1,2-dicarbonyl compounds, benzaldehydes, and ammonium acetate in the presence of 4 ? molecular sieves modified with titanium(IV) as an efficient heterogeneous catalyst. The catalyst could be recovered easily and reused without significant loss of activity.

Synthesis and anticancer activity of 2,4,5-triaryl imidazole derivatives

This study describes the synthesis of four 2,4,5-triarylimidazole derivatives and their anticancer activities. The target compounds were prepared from the reaction of benzaldehyde and benzoin derivatives in presence of ammonium acetate and ammonium vanadate. All the synthesized compounds were screened for anticancer activities against T47D and MDA-MB231 cell lines using the MTT assay. However, our obtained results indicated a significant difference between colchicines cytotoxicity and their homologs on treated MDA-MB231 and T47D cells; one compound (4a) showed a significant IC50 on MDA-MB231 cells in cell culture assay.