70451-01-3

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-
• CAS NO: 70451-01-3
• Molecular Formula: C17H15NO3
• Molecular Weight: 281.311
• Mol File: 70451-01-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-(70451-01-3)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-(70451-01-3)

Safety Data

• Hazardous Substances Data: 70451-01-3(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 63-91-2 L-phenylalanine 
• 4376-18-5 Monomethyl phthalate 
• 438470-19-0 methyl 2-(N-succinimidyloxycarbonyl)benzoate 
• 3182-95-4 L-Phenylalaninol 

Downstream Products

• 1333145-70-2 C₃₇H₅₅N₅O₈ 
• 1333145-86-0 C₃₆H₅₅N₅O₇ 
• 1333145-85-9 C₂HF₃O₂*C₂₉H₄₄N₄O₆ 
• 1333145-83-7 C₃₄H₅₂N₄O₈ 
• 1333145-78-0 (3S,5R)-5-benzyl-3-methylpyrrolidin-2-one 
• 1333145-88-2 C₂₂H₂₃NO₄ 
• 1333145-77-9 C₂₂H₂₃NO₄ 
• 1333145-76-8 C₂₂H₂₁NO₄ 
• 944804-63-1 (S)-N-(5-bromothiazol-2-yl)-N-(2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropyl)acetamide 
• 64715-80-6 (S)-1-benzyl-2-methoxyethylamine 
• 121612-80-4 5-((S)-1-Methoxymethyl-2-phenyl-ethylcarbamoyl)-7-methyl-thieno[2,3-b]pyridin-7-ium; iodide 
• 121612-85-9 (S)-1-methoxy-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-phenylpropane 
• 121612-74-6 (S)-(-)-1-methoxy-3-phenyl-N-(thieno<2,3-b>pyridine-5-carbonyl)propane-2-amine 

Relevant articles and documents

Nucleophilic Substitutions of Alcohols in High Levels of Catalytic Efficiency

A practical method for the nucleophilic substitution (SN) of alcohols furnishing alkyl chlorides, bromides, and iodides under stereochemical inversion in high catalytic efficacy is introduced. The fusion of diethylcyclopropenone as a simple Lewis base organocatalyst and benzoyl chloride as a reagent allows notable turnover numbers up to 100. Moreover, the use of plain acetyl chloride as a stoichiometric promotor in an invertive SN-type transformation is demonstrated for the first time. The operationally straightforward protocol exhibits high levels of stereoselectivity and scalability and tolerates a variety of functional groups.

Total synthesis of tubulysins U and V

Meeting the challenge: A reliable and modular reaction sequence has been developed for the synthesis of the challenging tubulysin framework. This route allows preparation of hundreds of milligrams of the stereochemically pure tetrapeptides (see picture), which are produced in small amounts by two different species of myxobacteria. Thus, full biological evaluation of the tubulysins and their analogues is now a real possibility. (Chemical Equation Presented).

Thiazole compounds and methods of use

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.