70452-19-6

Basic information

• Product Name: 5-bromo-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one
• Synonyms: 5-bromo-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one
• CAS NO: 70452-19-6
• Molecular Formula: C₁₆H₁₂BrNO₃
• Molecular Weight: 346.17538
• Mol File: 70452-19-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 560.3°Cat760mmHg
• Flash Point: 292.7°C
• Appearance: /
• Density: 1.576g/cm³
• Vapor Pressure: 2.17E-13mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 5-bromo-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one(70452-19-6)
• EPA Substance Registry System: 5-bromo-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one(70452-19-6)

Safety Data

• Hazardous Substances Data: 70452-19-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H12BrNO3/c17-11-6-7-13-12(8-11)16(21,15(20)18-13)9-14(19)10-4-2-1-3-5-10/h1-8,21H,9H2,(H,18,20)

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 98-86-2 acetophenone 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 1622878-69-6 C₁₈H₁₂BrN₃O 
• 183947-01-5 (E)-5-bromo-3-(2-oxo-2-phenylethylidene)indolin-2-one 
• 70452-30-1 5-bromo-3-(2-oxo-2-phenylethylidene)indolin-2-one 

Relevant articles and documents

Oxidative ring expansion of 3-hydroxy-3-phenacyloxindoles using phenyliodine diacetate and molecular iodine: Synthesis of 2-hydroxy-2-aryl/alkyl-2,3-dihydroquinolin-4(1H)-ones

Oxidation of tertiary alcohol of the type 3-hydroxy-3-phenacyloxindoles using the combination of phenyliodine diacetate and molecular iodine in methanol results in oxidative cleavage of C2-C3 bond to form isocyanate as an intermediate with its subsequent

"on Water" Catalytic Aldol Reaction between Isatins and Acetophenones: Interfacial Hydrogen Bonding and Enamine Mechanism

"On water" catalytic aldol reaction catalyzed by polyetheramine (D230) has been developed for easy access to 3-substituted 3-hydroxyindolin-2-ones through the reaction between various substituted isatins and acetophenones/cyclic ketones in high yields under room temperature. Systematic mechanism investigation uncovers the secret for the on water catalytic aldol reaction: comparison of the heterogeneous and homogeneous reaction circumstances with yields of 95 and 20%, respectively, indicates the on-water reaction dominating; interfacial hydrogen bonding between isatin with H2O is tested based on the downfield shift of the C2 and C3's 13C NMR signals when water was added to the CDCl3 solution of isatin; Lewis base polyetheramine D230 catalyzes the aldol reaction via the enamine mechanism verified by in situ NMR and ESI-MS analysis.

Hit optimization studies of 3-hydroxy-indolin-2-one analogs as potential anti-HIV-1 agents

In the current study, twenty-two compounds based upon 3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one nucleus were designed, synthesized and in vitro evaluated for HIV-1 RT inhibition and anti-HIV-1 activity. Compounds 3d, 5c and 5e demonstrated encouragin