70452-28-7

Basic information

• Product Name: 3-hydroxy-3-(2-oxo-2-pyridin-3-ylethyl)- 1,3-dihydro-indol-2-one
• Synonyms: 3-hydroxy-3-(2-oxo-2-pyridin-3-ylethyl)- 1,3-dihydro-indol-2-one
• CAS NO: 70452-28-7
• Molecular Formula: C₁₅H₁₂N₂O₃
• Molecular Weight: 268
• Mol File: 70452-28-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-hydroxy-3-(2-oxo-2-pyridin-3-ylethyl)- 1,3-dihydro-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-(2-oxo-2-pyridin-3-ylethyl)- 1,3-dihydro-indol-2-one(70452-28-7)
• EPA Substance Registry System: 3-hydroxy-3-(2-oxo-2-pyridin-3-ylethyl)- 1,3-dihydro-indol-2-one(70452-28-7)

Safety Data

• Hazardous Substances Data: 70452-28-7(Hazardous Substances Data)

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

Synthesis of functionalized 2-oxindoles by Friedel-Crafts reactions

A series of acetonyl-substituted 3-hydroxy-2-oxindoles have been prepared and reacted with arenes in superacid promoted Friedel-Crafts reactions. The product aryl-substituted 2-oxindoles are formed in generally good yields. With substituted arenes such as

Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2

Inhibitors of human transglutaminase 2 (TG2) are anticipated to be useful in the therapy of a variety of diseases including celiac sprue as well as certain CNS disorders and cancers. A class of 3-acylidene-2-oxoindoles was identified as potent reversible inhibitors of human TG2. Structure-activity relationship analysis of a lead compound led to the generation of several potent, competitive inhibitors. Analogs with significant non-competitive character were also identified, suggesting that the compounds bind at one or more allosteric regulatory sites on this multidomain enzyme. The most active compounds had Ki values below 1.0 μM in two different kinetic assays for human TG2, and may therefore be suitable for investigations into the role of TG2 in physiology and disease in animals.

Synthesis of 3-hydroxy-3-phenacyloxindole analogs

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