70458-73-0

Basic information

• Product Name: PEFLOXACIN IMPURITY B
• Synonyms: PEFLOXACIN IMPURITY B;1-Ethyl-6-chloro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;Pefloxacin Impurity 1
• CAS NO: 70458-73-0
• Molecular Formula: C17H20ClN3O3
• Molecular Weight: 349.81
• Mol File: 70458-73-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PEFLOXACIN IMPURITY B(CAS DataBase Reference)
• NIST Chemistry Reference: PEFLOXACIN IMPURITY B(70458-73-0)
• EPA Substance Registry System: PEFLOXACIN IMPURITY B(70458-73-0)

Safety Data

• Hazardous Substances Data: 70458-73-0(Hazardous Substances Data)

Usage

Uses

6-Chloro-1-ethyl-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid is used in the preparation of therapeutic diphosphonates.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 67681-88-3 6,7-dichloro-1-ethyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 109-86-4 2-methoxy-ethanol 

Relevant articles and documents

Substituted quinoline carboxylic acid derivatives

This invention relates to new compounds of value as antibacterial agents. More particularly, it relates to quinoline carboxylic acid derivatives, the hydrates and the acid or alkali addition salts thereof.

Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.