70459-07-3

Basic information

• Product Name: 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
• Synonyms: 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;Norfloxacin EP Impurity K;orfloxacin EP Impurity K;6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Monohydrochloride
• CAS NO: 70459-07-3
• Molecular Formula: C15H16FN3O3
• Molecular Weight: 305.3042432
• Mol File: 70459-07-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 551℃
• Flash Point: 287℃
• Appearance: /
• Density: 1.388
• CAS DataBase Reference: 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid(70459-07-3)
• EPA Substance Registry System: 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid(70459-07-3)

Safety Data

• Hazardous Substances Data: 70459-07-3(Hazardous Substances Data)

Usage

General Description

6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid is a fluoroquinolone antibiotic that is used to treat a variety of bacterial infections. It works by inhibiting the enzymes responsible for DNA replication and repair in bacteria, ultimately leading to their death. This chemical is a semi-synthetic derivative of the natural compound nalidixic acid and has a broad spectrum of activity against both gram-positive and gram-negative bacteria. It is commonly used to treat urinary tract infections, respiratory tract infections, and skin infections. However, due to its potential for serious side effects, such as tendon damage and central nervous system effects, it is generally reserved for the treatment of serious infections when other antibiotics are not suitable.

Upstream product

• 110-85-0 piperazine 
• 70032-16-5 7-chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 70459-06-2 7-Chlor-6-fluor-1-methyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeure-ethylester 
• 70032-30-3 diethyl 2-[(3-chloro-4-fluorophenylamino)methylene]malonate 
• 70458-93-4 7-Chloro-6-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester 
• 75073-15-3 ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate 

Relevant articles and documents

Developing ciprofloxacin analogues against plant DNA gyrase: A novel herbicide mode of action

Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.

Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.