70460-18-3

Basic information

• Product Name: 3'-HYDROXYFLAVONE
• Synonyms: 3'-HYDROXYFLAVONE;4H-1-Benzopyran-4-one,2-(3-hydroxyphenyl)-(9CI);2-(3-hydroxyphenyl)chromen-4-one;2-(3-hydroxyphenyl)chromone;2-(3-hydroxyphenyl)-4H-chromen-4-one
• CAS NO: 70460-18-3
• Molecular Formula: C₁₅H₁₀O₃
• Molecular Weight: 238.24
• Product Categories: FLAVONE
• Mol File: 70460-18-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 206-208°C
• Boiling Point: 437.7°Cat760mmHg
• Flash Point: 170.9°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 2.86E-08mmHg at 25°C
• Refractive Index: 1.666
• PKA: 9.01±0.10(Predicted)
• CAS DataBase Reference: 3'-HYDROXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-HYDROXYFLAVONE(70460-18-3)
• EPA Substance Registry System: 3'-HYDROXYFLAVONE(70460-18-3)

Safety Data

• Hazardous Substances Data: 70460-18-3(Hazardous Substances Data)

Usage

General Description

3'-Hydroxyflavone is a naturally occurring chemical compound that belongs to the flavonoid group. It is a derivative of flavone and is found in a variety of plants, including fruits, vegetables, and herbs. 3'-Hydroxyflavone has been studied for its potential antioxidant, anti-inflammatory, and anticancer properties. It has also shown potential as a neuroprotective agent and has been investigated for its ability to inhibit certain enzymes and pathways involved in inflammation and cancer. Additionally, 3'-hydroxyflavone has been explored for its potential application in the treatment of neurodegenerative diseases, cardiovascular diseases, and metabolic disorders. Overall, research on 3'-hydroxyflavone suggests that it may have therapeutic potential in various disease conditions, making it an interesting chemical compound for further study and development.

InChI:InChI=1/C15H10O3/c16-11-5-3-4-10(8-11)15-9-13(17)12-6-1-2-7-14(12)18-15/h1-9,16H

Upstream product

• 53906-83-5 3'-methoxyflavone 
• 85079-06-7 2-<(3-methoxybenzoyl)oxy>acetophenone 
• 1711-05-3 m-anisoyl chloride 
• 586-38-9 3-Methoxybenzoic acid 
• 84634-65-1 1-(2-hydroxyphenyl)-3-(3-methoxyphenyl)-1,3-propanedione 
• 121-71-1 3-Hydroxyacetophenone 
• 69404-96-2 methyl-2-<(tert-butyldimethylsilyl)oxy>benzoate 
• 119-36-8 methyl salicylate 
• 52600-91-6 1-(3-ethoxyphenyl)ethan-1-one 
• 7335-26-4 ethyl 2-methoxybenzoate 
• 34000-28-7 2'-hydroxy-3-methoxy-chalcone 
• 517892-03-4 3',4'-dihydroxyflavone-4'-β-D-glucopyranoside sodium salt 
• 517892-04-5 3',4'-dihydroxyflavone-4'-β-D-ribofuranoside sodium salt 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 119881-50-4 2-(3-acetoxy-phenyl)-6-diacetylamino-chromen-4-one 
• 405216-85-5 3'-(N,N-Dimethylcarbamoyloxy)flavone 

Relevant articles and documents

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

Microwave-assisted synthesis of novel bis-flavone dimers as new anticancer agents

In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Synthesis, in vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors

We report herein the synthesis, α-glucosidase inhibition and docking studies for a series of 3-15 new flavones. A simple nucleophilic substitution reaction takes place between 3′hydroxyflavone (2) with halides to afford the new flavones. Chalcone (1), 3′h