70461-91-5

Basic information

• Product Name: 5,5'-dihydroxyleucine
• CAS NO: 70461-91-5
• Molecular Weight: 163.174
• Mol File: 70461-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,5'-dihydroxyleucine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5'-dihydroxyleucine(70461-91-5)
• EPA Substance Registry System: 5,5'-dihydroxyleucine(70461-91-5)

Safety Data

• Hazardous Substances Data: 70461-91-5(Hazardous Substances Data)

Upstream product

• 133384-75-5 2,2-dimethyl-5-(2'-carbethoxy-2'diphenylmethylimino-ethane)-1,3-dioxane 
• 133384-74-4 2,2-dimethyl-5-(2-acetamido-2,2-dicarbethoxy-ethane)-1,3-dioxane 

Relevant articles and documents

SYNTHESIS OF 5,5'-DIHYDROXYLEUCINE AND 4-FLUORO-5,5'-DIHYDROXYLEUCINE, THE REDUCTION PRODUCTS OF 4-CARBOXYGLUTAMIC AND 4-CARBOXY-4-FLUOROGLUTAMIC ACIDS

Schemes for the synthesis of 5,5'-dihydroxyleucine 3 and its 4-fluoro analog 7 involving the condensation of a suitable 'aminoacid moiety' with 2,2-dimethyl-5-iodomethyl-1,3-dioxane 15D or its fluoro analog 27A were tested.The anion of the ethyl N-diphenylmethylene-glycinate 25 gave better yields of 3 than the classical anion of diethyl acetamidomalonate.This strategy could not be successfully applied to the synthesis of 7, which could be prepared by reduction of a suitably protected 4-fluoro-4-carboxyglutamate with BMS.