70476-65-2

Basic information

• Product Name: 1,4-Dihydroxy-5,8-bis((2-(4-morpholinyl)ethyl)amino)-9,10-anthracenedi one
• Synonyms: 1,4-Dihydroxy-5,8-bis((2-(4-morpholinyl)ethyl)amino)-9,10-anthracenedi one
• CAS NO: 70476-65-2
• Molecular Formula: C26H32N4O6
• Molecular Weight: 0
• Mol File: 70476-65-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 791.2°C at 760 mmHg
• Flash Point: 432.3°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 5.35E-26mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 1,4-Dihydroxy-5,8-bis((2-(4-morpholinyl)ethyl)amino)-9,10-anthracenedi one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydroxy-5,8-bis((2-(4-morpholinyl)ethyl)amino)-9,10-anthracenedi one(70476-65-2)
• EPA Substance Registry System: 1,4-Dihydroxy-5,8-bis((2-(4-morpholinyl)ethyl)amino)-9,10-anthracenedi one(70476-65-2)

Safety Data

• Hazardous Substances Data: 70476-65-2(Hazardous Substances Data)

Usage

Type

Anthracenedione derivative

Antineoplastic

It has the ability to inhibit the growth and proliferation of cancer cells.

Immunosuppressive

It suppresses the immune system, making it useful in treating autoimmune diseases.

Intercalates into DNA

It inserts itself between DNA base pairs, disrupting the DNA structure.

Inhibits topoisomerase II

It prevents the enzyme topoisomerase II from working, which is essential for DNA replication.

Disrupts synthesis of DNA and RNA

By inhibiting topoisomerase II, it stops the synthesis of DNA and RNA, thus preventing cell division and growth.

Chemotherapy agent

Used in the treatment of various types of cancer, such as leukemia, lymphoma, and breast cancer.

Treatment of multiple sclerosis

Utilized due to its immunosuppressive properties to manage the symptoms of multiple sclerosis.

Administration

Intravenous

Combination Therapy

Often used in combination with other chemotherapy drugs to enhance treatment effectiveness.

Bone marrow suppression

It can reduce the production of blood cells, leading to an increased risk of infections and anemia.

Nausea

A common side effect experienced by patients undergoing treatment with mitoxantrone.

Hair loss

A well-known side effect of chemotherapy, as the drug can affect the hair follicles and cause hair to fall out.

InChI:InChI=1/C26H32N4O6/c31-19-3-4-20(32)24-23(19)25(33)21-17(27-5-7-29-9-13-35-14-10-29)1-2-18(22(21)26(24)34)28-6-8-30-11-15-36-16-12-30/h1-4,27-28,31-32H,5-16H2

Relevant articles and documents

Metal chelates of 1,4-bis(substituted-amino-5,8-dihydroxy-anthraquinones

This disclosure describes metal chelates of symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones useful for inhibiting the growth of tumors and as colorants or dyes.