70490-85-6 Usage
Quinolinium derivative
A compound derived from the quinolinium structure, which is a heterocyclic aromatic compound.
Synthesis of pharmaceutical drugs and organic compounds
1-Methyl-4-amino-2-methylquinolinium is commonly used as an intermediate in the synthesis of various pharmaceutical drugs and organic compounds.
Potential as an anti-malarial agent
This compound has shown promise in the fight against malaria, a disease caused by parasites transmitted through the bite of infected mosquitoes.
Antiviral, antifungal, and antibacterial properties
1-Methyl-4-amino-2-methylquinolinium has been studied for its ability to inhibit the growth of viruses, fungi, and bacteria, making it a potential candidate for the development of new treatments for various infections.
Organic electronic devices
Due to its interesting photophysical properties, 1-Methyl-4-amino-2-methylquinolinium has been investigated for its potential application in organic electronic devices, such as organic light-emitting diodes (OLEDs) and organic solar cells.
Fluorogenic probe for the detection of biological amines
This compound has been utilized as a fluorogenic probe, which is a molecule that emits fluorescence upon binding to a target analyte, in this case, biological amines. This makes it a valuable tool in the field of analytical chemistry for detecting and quantifying these important molecules.
Diverse applications
1-Methyl-4-amino-2-methylquinolinium has a wide range of applications in various fields, including medicine, materials science, and analytical chemistry, making it an important chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 70490-85-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,4,9 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 70490-85:
(7*7)+(6*0)+(5*4)+(4*9)+(3*0)+(2*8)+(1*5)=126
126 % 10 = 6
So 70490-85-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2.HI/c1-8-7-10(12)9-5-3-4-6-11(9)13(8)2;/h3-7,12H,1-2H3;1H
70490-85-6Relevant articles and documents
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity
Teguh, Silvia C.,Klonis, Nectarios,Duffy, Sandra,Lucantoni, Leonardo,Avery, Vicky M.,Hutton, Craig A.,Baell, Jonathan B.,Tilley, Leann
, p. 6200 - 6215 (2013)
A novel class of antimalarial compounds, based on an indol-3-yl linked to the 2-position of a 4-aminoquinoline moiety, shows promising activity against the malaria parasite, Plasmodium falciparum. Compounds with a quaternary nitrogen on the quinoline show improved activity against the chloroquine-resistant K1 strain. Nonquaternerized 4-aminoquinolines retain significant potency but are relatively less active against the K1 strain. Alkylation of the 4-amino group preferentially improves the activity against the chloroquine-sensitive 3D7 strain. The quinoline-indoles show only weak activity as inhibitors of β-hematin formation, and their activities are only weakly antagonized by a hemoglobinase inhibitor. The compounds appear to dissipate mitochondrial potential as an early event in their antimalarial action and therefore may exert their activity by compromising Plasmodium mitochondrial function. Interestingly, we observed a structural relationship between our compounds and the anticancer and anthelminthic compound, pyrvinium pamoate, which has also been proposed to exert its action via compromising mitochondrial function.
