704910-29-2

Basic information

• Product Name: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-5-methyl-, methyl ester, (4S,5R)-
• CAS NO: 704910-29-2
• Molecular Formula: C13H15NO4
• Molecular Weight: 249.266
• Mol File: 704910-29-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-5-methyl-, methyl ester, (4S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-5-methyl-, methyl ester, (4S,5R)-(704910-29-2)
• EPA Substance Registry System: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(4-methoxyphenyl)-5-methyl-, methyl ester, (4S,5R)-(704910-29-2)

Safety Data

• Hazardous Substances Data: 704910-29-2(Hazardous Substances Data)

Upstream product

• 704910-28-1 (2S,3R)-3-hydroxy-2-(4-methoxybenzamido)-butyric acid methyl ester 
• 100-07-2 4-methoxy-benzoyl chloride 
• 928150-63-4 N,N-diethyl(α,α-difluoro-4-methoxybenzyl)amine 
• 3373-59-9 L-threonine methyl ester 
• 7465-86-3 4-methoxy-N,N-diethylbenzamide 

Downstream Products

• 704910-34-9 methyl (2R,3S)-1-(4-methoxybenzyl)-2-((benzyloxy)methyl)-3-hydroxy-3-methyl-4-methylene-5-oxopyrrolidine-2-carboxaldehyde 
• 704910-35-0 methyl (2R,3R)-1-(4-methoxybenzyl)-2-((benzyloxy)methyl)-3-hydroxy-3-methyl-4-methylene-5-oxopyrrolidine-2-carboxaldehyde 
• 704910-43-0 (2R,3R)-2-Benzyloxymethyl-2-(4-methoxy-benzylamino)-3-trimethylsilanyloxy-butyric acid methyl ester 
• 704910-33-8 methyl (R)-2-(N-(4-methoxybenzyl)acrylamido)-2-((benzyloxy)methyl)-3-oxybutanoate 
• 704910-32-7 methyl (2R,3R)-2-(N-(4-methoxybenzyl)acrylamido)-2-((benzyloxy)methyl)-3-hydroxybutanoate 
• 704910-31-6 methyl (2R,3R)-2-(4-methoxybenzylamino)-2-{(benzyloxy)methyl}-3-hydroxybutanoate 
• 860453-70-9 (2R,3S)-2-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propyl]-3-(iodomethyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyl)-3-methyl-4-methylene-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 860453-71-0 (3R,3aS,7aR)-3-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propyl]-2-(4-methoxy-benzyl)-3a,5,5-trimethyl-1-oxo-octahydro-4-oxa-2-aza-5-sila-indene-3-carboxylic acid methyl ester 
• 860453-76-5 (2R,3S,4R)-2-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propyl]-3-hydroxy-4-(2-hydroxy-ethyl)-1-(4-methoxy-benzyl)-3-methyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 860453-69-6 (2R,3S)-2-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propyl]-3-hydroxy-1-(4-methoxy-benzyl)-3-methyl-4-methylene-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 857311-65-0 (2R,3S)-2-Acetyl-2-[acryloyl-(4-methoxy-benzyl)-amino]-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentanoic acid methyl ester 
• 860453-68-5 (2R,3S)-2-Acetyl-3-(tert-butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzylamino)-4-methyl-pentanoic acid methyl ester 
• 860453-67-4 (4S,5R)-4-[(S)-1-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-propyl]-2-(4-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 860453-75-4 (4R,5R)-4-((S)-1-Hydroxy-2-methyl-propyl)-2-(4-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 

Relevant articles and documents

METHOD FOR PRODUCING 2-OXAZOLINE ANALOGUE OR 1,3-OXAZINE ANALOGUE

The present invention is a method for producing a 2-oxazoline analogue or a 1,3-oxazine analogue represented by the following general formula (3) by reacting a 1,2-aminoalcohol compound or a 1,2-aminothiol compound with an α,α-dihaloamine compound. (In the formula, n represents 0 or 1, and R represents an oxygen atom or a sulfur atom. R1, R2 and R3 each represents an atom or a group shown in Group 1 to Group 3, and R° represents an atom or a group shown in Group 2 or Group 3. Two or more of R1, R2 and R3 may be bonded to each other to form a ring. Group 1: a hydrogen atom, a halogen atom, a nitro group, a cyano group, a formyl group, a carboxyl group, a sulfonyl group, a sulfinoyl group or a sulfenyl group; Group 2: an alkyl group, which may have an arbitrary substituent, an aryl group or an aralkyl group; and Group 3: an alkyl-substituted, aryl-substituted or aralkyl-substituted oxy group, a carbonyl group, an oxycarbonyl group, a carbonyloxy group, a thio group, a sulfonyl group, a sulfinoyl group or a sulfenyl group)

ANALOGS OF SALINOSPORAMIDE A

Disclosed herein are analogs of Salinosporamide A, having the Formulae Ia - IVa as follows: [insert chemical formula here] Like Salinosporamide A, the compounds of the present invention will inhibit the proteasome, an intracellular enzyme complex that destroys proteins the cell no longer needs. Without the proteasome, proteins would build up and clog cellular machinery. Fast-growing cancer cells make especially heavy use of the proteasome, so thwarting its action is a compelling drug strategy.

A simple stereocontrolled synthesis of salinosporamide A

A simple and effective stereocontrolled synthesis of salinosporamide A has been developed. This process, the first synthesis of salinosporamide A, is capable of providing the compound in substantial quantities for further biological studies. Salinosporamide A was of special interest as a synthetic target because of its potent in vitro cytotoxic activity against many tumor cell lines (IC50 values of 10 nM or less). Copyright