704912-42-5

Basic information

• Product Name: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7,8,9-trimethoxy-
• Synonyms: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7,8,9-trimethoxy-
• CAS NO: 704912-42-5
• Molecular Formula: C21H17N3O4
• Molecular Weight: 375.37738
• Mol File: 704912-42-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7,8,9-trimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7,8,9-trimethoxy-(704912-42-5)
• EPA Substance Registry System: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7,8,9-trimethoxy-(704912-42-5)

Safety Data

• Hazardous Substances Data: 704912-42-5(Hazardous Substances Data)

Upstream product

• 5035-82-5 methyl 3,4,5-trimethoxyanthranilate 
• 34535-42-7 2,3-dihydro[1H]-pyrrolo[3,4-b]quinolin-3-one 

Relevant articles and documents

Synthesis and topoisomerase I inhibitory properties of luotonin A analogues

Luotonin A, a naturally occurring pyrroloquinazolinoquinoline alkaloid, has been previously demonstrated to be a topoisomerase I poison. A number of luotonin A derivatives have now been prepared through the condensation of anthranilic acid derivatives and 1,2-dihydropyrrolo[3,4-b]quinoline-3-one in the presence of phosphorus oxychloride. When dichloromethane was used as solvent the reaction proceeded to a single product. In contrast when the reaction was carried out in tetrahydrofuran or in phosphorus oxychloride, an additional isomeric product was obtained. The luotonin A analogues were evaluated for their ability to effect stabilization of the covalent binary complex formed between human topoisomerase I and DNA, and for cytotoxicity toward a yeast strain expressing the human topoisomerase I.