705-02-2

Basic information

• Product Name: (2-FLUOROPHENYL)THIO]ACETIC ACID
• Synonyms: Aceticacid, [(2-fluorophenyl)thio]- (9CI); Acetic acid, [(o-fluorophenyl)thio]-(7CI,8CI); (2-Fluorophenylsulfanyl)acetic acid; [(2-Fluorophenyl)thio]aceticacid
• CAS NO: 705-02-2
• Molecular Formula: C₈H₇FO₂S
• Molecular Weight: 186.205
• Mol File: 705-02-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 297.6°C at 760 mmHg
• Flash Point: 133.8°C
• Appearance: /
• Vapor Pressure: 0.000602mmHg at 25°C
• CAS DataBase Reference: (2-FLUOROPHENYL)THIO]ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2-FLUOROPHENYL)THIO]ACETIC ACID(705-02-2)
• EPA Substance Registry System: (2-FLUOROPHENYL)THIO]ACETIC ACID(705-02-2)

Safety Data

• Hazardous Substances Data: 705-02-2(Hazardous Substances Data)

Usage

Uses

2-[(2-fluorophenyl)sulfanyl]acetic acid (cas# 705-02-2) is used in the preparation of phenylsulfanylalkylcarboxylic acid compositions, useful for the delivery of active agents.

InChI:InChI=1/C8H7FO2S/c9-6-3-1-2-4-7(6)12-5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 655-20-9 2-fluorothioanisole 
• 2557-78-0 2-fluorothiophenol 
• 79-11-8 chloroacetic acid 
• 68-11-1 mercaptoacetic acid 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 2557-78-0 2-fluorothiophenol 
• 298-12-4 Glyoxilic acid 

Relevant articles and documents

RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases

A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media

ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.

KINETICS AND MECHANISM OF OXIDATION OF (ARYLTHIO)ACETIC ACIDS BY PYRIDINIUM HYDROBROMIDE PERBROMIDE

Oxidation of several monosubstituted (phenylthio)acetic acids (PTAA) by pyridinium hydrobromide perbromide (PHPB) was studied in aqueous acetic acid.The reaction is first order with respect to PHPB.Michaelis-Menten type kinetics are observed with respect to (arylthio)acetic acid.The effect of solvent composition indicates that the transition state is more polar than the reactants.The formation constants of the intermediate substrate-PHPB complexes and the rates of their decomposition were determined at different temperatures.The rates of oxidation of para and meta-substituted (phenylthio)acetic acids were correlated with Hammett's substituent constants.The ρ value is -1.60 at 35 deg c.The rates of oxidation of ortho substituted compounds are correlated with Charton's triparametric equation.A mechanism involving the decomposition of the intermediate complex in the slow rate-determining step affording a sulphonium ion which hydrolyses in a subsequent fast step to the sulphoxide is proposed.