705-83-9

Basic information

• Product Name: 3-(3-fluorophenyl)propiolic acid
• Synonyms: 3-(3-fluorophenyl)propiolic acid;3-(3-FLUOROPHENYL)PROP-2-YNOIC ACID;(3-Fluoro-phenyl)-propynoic acid
• CAS NO: 705-83-9
• Molecular Formula: C₉H₅FO₂
• Molecular Weight: 164.1332032
• Mol File: 705-83-9.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-fluorophenyl)propiolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-fluorophenyl)propiolic acid(705-83-9)
• EPA Substance Registry System: 3-(3-fluorophenyl)propiolic acid(705-83-9)

Safety Data

• Hazardous Substances Data: 705-83-9(Hazardous Substances Data)

Usage

General Description

3-(3-fluorophenyl)propiolic acid is a chemical compound with the molecular formula C9H6F2O2. It is a derivative of propiolic acid, containing a 3-fluorophenyl group. 3-(3-fluorophenyl)propiolic acid is used in organic synthesis and can undergo various chemical reactions, such as nucleophilic addition and substitution reactions. The presence of the fluorine atom in the phenyl ring provides specific reactivity and properties to this compound, making it useful for the development of new materials and pharmaceuticals. Additionally, 3-(3-fluorophenyl)propiolic acid may have potential applications in the field of medicinal chemistry and drug discovery due to its unique chemical structure and properties.

Upstream product

• 124-38-9 carbon dioxide 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 471-25-0 Propiolic acid 
• 221148-38-5 methyl 3-(3-fluorophenyl)prop-2-ynoate 

Downstream Products

• 52112-24-0 1-fluoro-3-(prop-1-yn-1-yl)benzene 
• 406687-60-3 {[3-(3-fluoro-phenyl)-propynoyl]-methyl-amino}-acetic acid ethyl ester 
• 849150-02-3 3-(3-fluoro-phenyl)-1-methyl-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid ethyl ester 
• 1431960-65-4 C₁₆H₁₉FN₂O₃ 
• 1431960-66-5 C₁₁H₁₁FN₂O 
• 1431959-41-9 N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate 
• 633327-36-3 (E)-2-(3-fluorostyryl)-4,4,5,5-tetramethyl-1,3-dioxa-2-borolane 
• 1174916-26-7 diethyl ((3-fluorophenyl)ethynyl)phosphonate 

Relevant articles and documents

N-Heterocyclic carbene-nitrogen molybdenum catalysts for utilization of CO2

Three new N-heterocyclic carbene-nitrogen molybdenum complex was synthesized, and its catalytic activity was evaluated in the cycloaddition of epoxides with CO2. The molybdenum complex combined with tetrabutyl ammonium iodide (TBAI) resulted in a catalytic system for efficient conversion of a wide range of terminal and internal epoxides under 80 °C and 5–7 bar pressure for CO2. The cooperative catalysis mechanism between molybdenum complex and TBAI was elucidated, in which molybdenum complex was used as Lewis acid, and TBAI was employed as nucleophilic reagent. In addition, the NHC-Mo catalytic system was also successfully applied for the direct carboxylation of terminal alkynes with CO2.

Microwave-assisted fabrication of a mixed-ligand [Cu4(μ3-OH)2]-cluster-based metal–organic framework with coordinatively unsaturated metal sites for carboxylation of terminal alkynes with carbon dioxide

The development of efficient and stable metal–organic framework (MOF) catalysts with coordinatively unsaturated metal sites for modern organic synthesis is greatly important. Herein, a robust [Cu4(μ3-OH)2]-cluster-based MOF (Cu-MOF) with a mixed-ligand system was successfully fabricated by a microwave-assisted method under mild conditions. The as-prepared Cu-MOF catalyst possessing unsaturated Cu (II) sites exhibited excellent catalytic activity toward the direct carboxylation of 1-ethynylbenzene with CO2, and various propiolic acid derivatives were synthesized in moderate to good yields under optimized reaction conditions. Furthermore, the catalyst remained stable and could be easily recycled for five sequential runs without incredible decrease in catalytic efficiency.

Visible light induced 3-position-selective addition of arylpropiolic acids with ethersviaC(sp3)-H functionalization

Although the 2-position-selective decarboxylative coupling or addition of arylpropiolic acids with cyclic ethers has been intensively investigated, selective functionalization of arylpropiolic acids at the 3-position is still a big challenge. Herein, an i