705255-05-6

Basic information

• Product Name: 5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene-2-N-tritylguanosine
• Synonyms: 5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene-2-N-tritylguanosine
• CAS NO: 705255-05-6
• Molecular Weight: 679.891
• Mol File: 705255-05-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene-2-N-tritylguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene-2-N-tritylguanosine(705255-05-6)
• EPA Substance Registry System: 5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene-2-N-tritylguanosine(705255-05-6)

Safety Data

• Hazardous Substances Data: 705255-05-6(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 87619-81-6 2',3'-O-isopropylidene-5'-O-(tert-butyldimethylsilyl)guanosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 362-76-5 2',3'-isopropylideneguanosine 

Downstream Products

• 26783-32-4 2-amino-6-(benzylamino)-9-(β-D-ribofuranosyl)purine 

Relevant articles and documents

Functionalization of Guanosine and 2′-Deoxyguanosine at C6: A Modified Appel Process and SNAr Displacement of Imidazole

Treatment of sugar-protected 2-N-trityl derivatives of guanosine and 2′-deoxyguanosine with imidazole/triphenylphosphine/iodine/ethyldiisopropylamine gives the corresponding 6-(imidazol-1-yl)-2-(tritylamino)purine nucleosides. S NAr displacement of the imidazole moiety with nucleophiles provides 2-amino-6-substituted-purine nucleosides and 2′-deoxynucleosides.