70529-35-0

Basic information

• Product Name: Itazigrel
• Synonyms: Itazigrel;4,5-Bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole;LY-108048;U-53059;4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1,3-thiazole
• CAS NO: 70529-35-0
• Molecular Formula: C₁₈H₁₄F₃NO₂S
• Molecular Weight: 365.37
• Mol File: 70529-35-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 400.3°C at 760 mmHg
• Flash Point: 195.9°C
• Appearance: /
• Density: 1.285g/cm³
• Vapor Pressure: 2.96E-06mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: Itazigrel(CAS DataBase Reference)
• NIST Chemistry Reference: Itazigrel(70529-35-0)
• EPA Substance Registry System: Itazigrel(70529-35-0)

Safety Data

• Hazardous Substances Data: 70529-35-0(Hazardous Substances Data)

Usage

Uses

Platelet aggregation inhibitor.

InChI:InChI=1/C18H14F3NO2S/c1-23-13-7-3-11(4-8-13)15-16(25-17(22-15)18(19,20)21)12-5-9-14(24-2)10-6-12/h3-10H,1-2H3

Upstream product

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Relevant articles and documents

Synthesis and Platelet Aggregation Inhibitory Activity of 4,5-Bis(aryl)-2-substituted-thiazoles

In our continuing effort to discover compounds which inhibit collagen-induced platelet aggregation, we have screened compounds in a mouse pulmonary thromboembolism screen.Methyl 4,5-bis(4-methoxyphenyl)-2-thiazoleacetate (3) was very active in the above screen.However, 3 was active for less than 5 min when given orally to guinea pigs.As a result, our synthetic goal was to prepare 2-substituted thiazoles with a much longer duration of activity.This paper describes the preparation of a number 4,5-bis(aryl)-2-substituted-thiazoles and their in vitro and ex vivo activity against collagen-induced platelet aggregation.It was determined that 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole (16) is the most promising compound.