70547-50-1

Basic information

• Product Name: 5-METHYL-2-(4-PYRIDINYL)-1,3-THIAZOL-4-OL
• Synonyms: 5-METHYL-2-(4-PYRIDINYL)-1,3-THIAZOL-4-OL;5-Methyl-2-(4-pyridinyl)-1,4-thiazol-4-ol;2-methyl-5-(pyridin-4-yl)thiazol-3(2H)-ol
• CAS NO: 70547-50-1
• Molecular Formula: C₉H₈N₂OS
• Molecular Weight: 192.24
• Mol File: 70547-50-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 221-225°C
• Boiling Point: 398.6 °C at 760 mmHg
• Flash Point: 194.9 °C
• Appearance: /
• Density: 1.322 g/cm³
• Vapor Pressure: 6.32E-07mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 5-METHYL-2-(4-PYRIDINYL)-1,3-THIAZOL-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-2-(4-PYRIDINYL)-1,3-THIAZOL-4-OL(70547-50-1)
• EPA Substance Registry System: 5-METHYL-2-(4-PYRIDINYL)-1,3-THIAZOL-4-OL(70547-50-1)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 70547-50-1(Hazardous Substances Data)

Usage

General Description

5-Methyl-2-(4-pyridinyl)-1,3-thiazol-4-ol is a chemical compound with the molecular formula C8H7NOS. It is a heterocyclic compound containing a thiazole ring with a methyl group at the 5-position and a pyridine ring at the 2-position. Thiazoles are known for their diverse biological activities, including antimicrobial, antiviral, antifungal, anticancer, and anti-inflammatory properties. The presence of a pyridinyl group in this compound also suggests potential pharmacological activity. As a result, it may be of interest to researchers and pharmaceutical companies for further investigation into its potential medicinal and therapeutic applications.

InChI:InChI=1/C9H8N2OS/c1-6-8(12)11-9(13-6)7-2-4-10-5-3-7/h2-5,12H,1H3

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 79-42-5 2-mercaptopropanoic acid 
• 6959-64-4 (+)-thiolactic acid 
• 5445-17-0 Methyl 2-bromopropionate 
• 2196-13-6 pyridine-4-carbothioamide 

Downstream Products

• 1279103-58-0 2-(2,6-difluoro-phenyl)-5-(5-methyl-2-pyridin-4-yl-thiazol-4-yl)-1H-indole 
• 1279106-62-5 Benzenesulfonyl-2-(2,6-difluoro-phenyl)-5-(5-methyl-2-pyridin-4-yl-thiazol-4-yl)-1H-indole 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine H3R ligands

Histamine H3 receptor (H3R) is largely expressed in the CNS and modulation of the H3R function can affect histamine synthesis and liberation, and modulate the release of many other neurotransmitters. Targeting H3R with antagonists/inverse agonists may have therapeutic applications in neurodegenerative disorders, gastrointestinal and inflammatory diseases. This prompted us to design and synthesize azole-based H3R ligands, i.e. having oxadiazole- or thiazole-based core structures. While ligands of oxadiazole scaffold were almost inactive, thiazole-based ligands were very potent and several exhibited binding affinities in a nanomolar concentration range. Ligands combining 4-cyanophenyl moiety as arbitrary region, para-xylene or piperidine carbamoyl linkers, and/or pyrrolidine or piperidine basic heads were found to be the most active within this series of thiazole-based H3R ligands. The most active ligands were in silico screened for ADMET properties and drug-likeness. They fulfilled Lipinski's and Veber's rules and exhibited potential activities for oral administration, blood–brain barrier penetration, low hepatotoxicity, combined with an overall good toxicity profile.

BENZOXAZINE DERIVATIVES AS CRAC MODULATORS

Compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with calcium release-activated calcium channels (CRAC).

Hydroxythiazole-based fluorescent probes for fluoride ion detection

This work describes the synthesis of five O-silyloxy-1,3-thiazoles and their use as fast-response "turn-on" probes for fluoride ion detection in polar aprotic solvents and in aqueous cetyltrimethylammonium bromide micellar medium. The fluoride-triggered d