70585-49-8

Basic information

• Product Name: 5-CHLOROQUINOLINE-8-CARBOXYLIC ACID
• Synonyms: 5-CHLOROQUINOLINE-8-CARBOXYLIC ACID
• CAS NO: 70585-49-8
• Molecular Formula: C₁₀H₆ClNO₂
• Molecular Weight: 207.61314
• Mol File: 70585-49-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-CHLOROQUINOLINE-8-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROQUINOLINE-8-CARBOXYLIC ACID(70585-49-8)
• EPA Substance Registry System: 5-CHLOROQUINOLINE-8-CARBOXYLIC ACID(70585-49-8)

Safety Data

• Hazardous Substances Data: 70585-49-8(Hazardous Substances Data)

Usage

General Description

5-Chloroquinoline-8-carboxylic acid is an organic compound with the molecular formula C10H6ClNO2. It is a derivative of quinoline and contains a chlorine atom and a carboxylic acid group attached to the quinoline ring. 5-chloroquinoline-8-carboxylic acid is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential biological activities and has been studied for its anti-inflammatory and anti-tumor properties. Its structure and properties make it a useful building block for the production of various drugs and other organic compounds in the pharmaceutical and chemical industries.

Upstream product

• 56-81-5 glycerol 
• 89-77-0 2-Amino-4-chlorobenzoic acid 

Downstream Products

• 1438559-27-3 (5-chloroquinolin-8-yl)(phenyl)methanone 
• 1438559-55-7 1-(5-chloroquinolin-8-yl)ethanone 

Relevant articles and documents

Method for preparing 8-quinoline carboxylic acid and derivatives of 8-quinoline carboxylic acid

The invention discloses a method for preparing 8-quinoline carboxylic acid and derivatives thereof, which comprises the following steps: by using a compound I as a raw material, reacting with an oxidant at the temperature of 50-150 DEG C under normal pressure in a solvent under the action of a Cu-Co-X ternary composite catalyst to obtain a compound II; according to the method, the efficient Cu-Co-X ternary composite catalyst is adopted, the reaction is carried out at the temperature of 50-150 DEG C under normal pressure, the reaction condition is mild, the oxidation yield is remarkably increased, near-zero emission of three wastes is realized, the pollution problem is effectively solved, and the production cost is greatly reduced.

Direct exchange of a ketone methyl or aryl group to another aryl group through ciC bond activation assisted by rhodium chelation

Swapped: Commercially available quinolinone derivatives (1 or 2, see scheme) were reacted with arylboronic acids in the presence of a RhI complex to give aryl(quinolin-8-yl)methanone products 3 in medium to good yields. A mechanism that involves the in situ oxidation of RhI to RhIII by O2 in the presence of CuI was proposed. Copyright