70593-61-2

Basic information

• Product Name: 6-Chloropyridine-2-carboxamide
• Synonyms: 6-Chloropyridine-2-carboxamide;6-chloropicolinamide;2-Carbamoyl-6-chloropyridine;6-chloro-2-pyridinecarboxaMide;2-Pyridinecarboxamide,6-chloro
• CAS NO: 70593-61-2
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.5697
• EINECS: -0
• Mol File: 70593-61-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 0.000535mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 14.49±0.50(Predicted)
• CAS DataBase Reference: 6-Chloropyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloropyridine-2-carboxamide(70593-61-2)
• EPA Substance Registry System: 6-Chloropyridine-2-carboxamide(70593-61-2)

Safety Data

• Hazardous Substances Data: 70593-61-2(Hazardous Substances Data)

Usage

General Description

6-Chloropyridine-2-carboxamide, also known as 6-Chloronicotinamide, is a chemical compound with the molecular formula C6H5ClN2O. It is a white to light yellow crystalline solid that is slightly soluble in water and organic solvents. 6-Chloropyridine-2-carboxamide is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in the production of dyes and pigments. 6-Chloropyridine-2-carboxamide is known for its heterocyclic structure, which makes it a valuable building block in the development of various chemical compounds. Additionally, it is important to handle this chemical with care as it can be hazardous if not used and stored properly.

InChI:InChI=1/C6H5ClN2O/c7-5-3-1-2-4(9-5)6(8)10/h1-3H,(H2,8,10)

Upstream product

• 629-11-8 1,6-hexanediol 
• 33252-29-8 6-chloro-pyridine-2-carbonitrile 
• 64-17-5 ethanol 
• 104727-52-8 ethyl 6-chloropyridine-2-carboximidate 
• 109-09-1 2-chloropyridine 
• 2402-95-1 2-chloropyridine-N-oxide 
• 116570-79-7 N-methoxy-2-chloropyridinium methylsulfate 
• 4684-94-0 6-chloropicolinic acid 
• 77287-34-4 formamide 

Downstream Products

• 935265-54-6 6-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)picolinamide 
• 935265-04-6 C₂₂H₂₅N₃O₃ 
• 1012330-19-6 6-(2-(3-(biphenyl-4-yl)-1-(tert-butyldimethylsilyloxy)propyl)oxazol-5-yl)pyridine-2-carboxamide 
• 1012329-92-8 C₂₄H₂₁N₃O₂ 

Relevant articles and documents

Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.

CXCR4 Receptor Antagonists

Disclosed are compounds that are antagonists of the CXCR4 receptor.

SOLVENT AND TEMPERATURE DEPENDENT REGIOSELECTIVE REACTIONS BETWEEN 2-CHLORO-6-CYANOPYRIDINE AND ALIPHATIC ALCOHOLS

Reaction of 2-chloro-6-cyanopyridine with aliphatic mono- and di-alcohols or ethylene glycols affords, depending on the reaction conditions, alkoxypyridines or imino ester pyridines or a mixture of both types of compounds.It is suggested that the product distribution is determined by the stability of an imidate anion formed as an intermediate.An improved synthesis of 2-chloro-6-cyanopyridine is also described.