705951-09-3

Basic information

• Product Name: C₂₈H₄₄N₂O₇Si
• CAS NO: 705951-09-3
• Molecular Weight: 548.752
• Mol File: 705951-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₄₄N₂O₇Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₄₄N₂O₇Si(705951-09-3)
• EPA Substance Registry System: C₂₈H₄₄N₂O₇Si(705951-09-3)

Safety Data

• Hazardous Substances Data: 705951-09-3(Hazardous Substances Data)

Upstream product

• 626-15-3 1,3-bis-(bromomethyl)benzene 
• 82938-50-9 (4S)-N-tert-butyldimethylsilylazetidin-2-one-4-carboxylic acid 
• 188715-39-1 3-(bromomethyl)phenyl-N,N-bis(tert-butoxycarbonyl)methanamine 

Downstream Products

• 705951-17-3 C₂₉H₃₆N₂O₇ 

Relevant articles and documents

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase

Azetidinones such as BMS-363131 (2) and BMS-363130 (3), which contain a guanidine group in the C-3 side chain were previously shown to be very potent inhibitors of human tryptase with high selectivity versus other serine proteases, including trypsin. In this letter, we describe the discovery of a number of potent azetidinone tryptase inhibitors in which the guanidine moiety at the ring C-3 position is replaced with primary or secondary amine or aminopyridine functionality. In particular, BMS-354326 (4) is a highly potent tryptase inhibitor (IC50=1.8nM), which has excellent selectivity against trypsin and most other related serine proteases.