70627-21-3

Basic information

• Product Name: 4-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE
• Synonyms: CHEMBRDG-BB 3014202;AURORA 23293;ART-CHEM-BB B014202;ASISCHEM N40487;4-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE;4-[(2-CHLOROBENZYL)OXY]BENZENECARBALDEHYDE;AKOS B014202;OTAVA-BB BB7110952589
• CAS NO: 70627-21-3
• Molecular Formula: C₁₄H₁₁ClO₂
• Molecular Weight: 246.69
• Mol File: 70627-21-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 393.9°C at 760 mmHg
• Flash Point: 164.7°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 2.07E-06mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 4-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE(70627-21-3)
• EPA Substance Registry System: 4-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE(70627-21-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 70627-21-3(Hazardous Substances Data)

Usage

General Description

4-[(2-chlorobenzyl)oxy]benzaldehyde is a chemical compound belonging to the class of benzaldehydes. It is a yellowish liquid with a molecular formula of C14H11ClO2 and a molecular weight of 248.69 g/mol. 4-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE is commonly used in organic synthesis and as an intermediate in the production of other chemicals. It is also used in the preparation of pharmaceuticals, agrochemicals, and fragrances. Additionally, it has potential applications in the field of medicinal chemistry and drug development due to its unique chemical properties.

InChI:InChI=1/C14H11ClO2/c15-14-4-2-1-3-12(14)10-17-13-7-5-11(9-16)6-8-13/h1-9H,10H2

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 

Downstream Products

• 1327288-02-7 (Z)-4-[4-(2-chlorobenzyloxy)benzylidene]-3-[4-(trifluoromethyl)phenyl]isoxazol-5(4H)-one 
• 1239479-94-7 C₂₀H₁₆ClN₃O 
• 1392419-44-1 C₂₄H₁₅ClF₃NO₃ 
• 1392418-46-0 C₃₀H₁₉ClF₃NO₄ 
• 1414806-59-9 (S,E)-2-(5-(4-(2-chlorobenzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells

Sodium taurocholate cotransport polypeptide (NTCP) plays an important role in the development of hepatitis and acts as a switch to allow hepatitis virus to enter hepatic cells. As the entry receptor protein of hepatitis virus, NTCP is also an effective ta

Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone

Four novel series of compounds, including the l-phenylalanine-derived C5-substituted rhodanine (6a-q, 7a-j) and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone (9a-e, 11a-e) have been designed, synthesized, characterized, and evaluated for their antibacterial activity. Some of these compounds showed significant antibacterial activity against Gram-positive bacterias, especially against the strains of multidrug-resistant clinical isolates, among which compounds 6c-e, 6g, 6i, 6j and 6q exhibiting high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentration (MIC) values of 2 μg/mL. Compound 6q showed the most potent activity of all of the compounds against all of the test multidrug-resistant clinical isolates tested. Unfortunately, however, none of the compounds were active against Gram-negative bacteria at 64 μg/mL.

Selective and potent monoamine oxidase type B inhibitors: substituted semicarbazones and acylhydrazones of aromatic aldehydes and ketones

The synthesis and the evaluation of the monoamine oxidase A and B inhibitory activities of 21 new substituted acylhydrazones of various aromatic aldehydes and 4-(benzyloxy)acetophenone, and four substituted semicarbazones of benzaldehyde and 4-(benzyloxy)benzaldehyde, are described.The 4-(benzyloxy)phenyl group contributing to a high lipophilicity led to the most active compounds.One of these, compound 3g (IC50 = 3 nM, MAO A/MAO B selectivity > 33 000), was found to act as a revervible and probably tight-binding inhibitor.The studied acyclic hydrazones and semicarbazones are structurally related to other reversible and potent inhibitors, eg, heterocyclic compounds such as 1,3,4-oxadiazol-2(3H)-one derivatives in which the hydrazono group is intracyclic.Some of these new inhibitors might find use in the symptomatic treatment of neurodegenerative processes.MAO B inhibitor / hydrazone (aromatic acyl-) / semicarbazone (aromatic)