70639-65-5 Usage
General Description
1-Methylisoguanosine is a nucleoside derivative that belongs to the family of modified guanosine nucleosides. It is composed of a guanosine base linked to a ribose sugar molecule, with a methyl group attached to the nitrogen atom at position 1 of the guanine ring, hence the name "1-Methylisoguanosine". This chemical compound has been identified in various biological sources, including transfer ribonucleic acids (tRNAs) and viral RNA. It plays a role in modulating the structure and function of RNA molecules, and is involved in regulating protein synthesis and gene expression. Additionally, 1-Methylisoguanosine has been studied for its potential therapeutic applications in cancer biology and antiviral drug development, due to its ability to influence RNA metabolism and RNA-protein interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 70639-65-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,6,3 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 70639-65:
(7*7)+(6*0)+(5*6)+(4*3)+(3*9)+(2*6)+(1*5)=135
135 % 10 = 5
So 70639-65-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N5O5/c1-15-8(12)5-9(14-11(15)20)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2,12H2,1H3/t4-,6-,7-,10-/m1/s1
70639-65-5Relevant articles and documents
Nucleosides. 3. Reactions of AICA-Riboside with Isothiocyanates. A Convenient Synthesis of Isoguanosine and Xanthosine Derivatives
Chern, Ji-Wang,Lin, Gwo-Sen,Chen, Chien-Shu,Townsend, Leroy B.
, p. 4213 - 4218 (2007/10/02)
Cyclodesulfurative annulations of 5--1-(β-D-ribofuranosyl)imidazole-4-carboxamides (3a-h) with N,N-dicyclohexylcarbodiimide are described.Isoguanosine (4) and several 1-substituted isoguanosines 6a-f,h are readily prepared by a ring closure of the appropriate resulting 5-(3-substituted-1-ureido)-1-(β-D-ribofuranosyl)imidazole-4-carbonitriles 5a-h.Treatment of the appropriate 1-substituted isoguanosines under basic conditions has furnished the corresponding 1-substituted xanthosine 12.
