70639-94-0

Basic information

• Product Name: 1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one
• Synonyms: 1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one;2-Propyn-1-one, 1-cyclopentyl-3-(trimethylsilyl)-;3-cyclopentyl-1-trimethylsilyl-1-propyn-3-one
• CAS NO: 70639-94-0
• Molecular Formula: C₁₁H₁₈OSi
• Molecular Weight: 194.34552
• Mol File: 70639-94-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one(70639-94-0)
• EPA Substance Registry System: 1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one(70639-94-0)

Safety Data

• Hazardous Substances Data: 70639-94-0(Hazardous Substances Data)

Usage

General Description

1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one is a chemical compound with the molecular formula C10H18OSi. It is a propargyl ketone derivative that contains a cyclopentyl group and a trimethylsilyl group. 1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one is commonly used in organic synthesis as a reagent for the preparation of various organic compounds. It is also used as a building block in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 1-cyclopentyl-3-(triMethylsilyl)prop-2-yn-1-one exhibits unique chemical properties that make it a valuable tool for research and development in the field of organic chemistry.

Upstream product

• 4524-93-0 Cyclopentanecarboxylic acid chloride 
• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 72096-97-0 3-cyclopentyl-1-trimethylsilyl-1,2-propadiene 
• 167303-65-3 N-Cyclopentanecarbonyl-N,O-dimethylhydroxylamine 
• 1066-54-2 trimethylsilylacetylene 
• 3400-45-1 cyclopentanecarboxylic acid 

Downstream Products

• 70639-95-1 cyclopentyl ethynyl ketone 
• 625445-74-1 6-Cyclopentyl-6-[2-(3-fluoro-4-methoxy-phenyl)-ethyl]-dihydro-pyran-2,4-dione 
• 625445-71-8 6-[2-(3-chloro-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-dihydro-pyran-2,4-dione 
• 749928-76-5 2-{4-[3-cyclopentyl-4-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-3-hydroxybutyl]-2-fluorophenyl}-2-methyl-propionitrile 
• 749928-75-4 2-{4-[2-(2-cyclopentyl-4,6-dioxo-tetrahydro-pyran-2-yl)-ethyl]-2-fluoro-phenyl}-2-methyl-propionitrile 
• 749929-33-7 2-[4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)-2-fluorophenyl]-2-methylpropanenitrile 
• 945619-11-4 C₂₂H₂₅ClO₅ 
• 945619-18-1 C₂₂H₂₉ClO₅ 
• 945619-12-5 C₂₂H₂₅FO₅ 
• 945619-19-2 C₂₂H₂₉FO₅ 
• 945619-13-6 C₂₃H₂₈O₅ 
• 945619-20-5 C₂₃H₃₂O₅ 
• 625445-73-0 6-Cyclopentyl-6-[2-(4-methoxy-3-methyl-phenyl)-ethyl]-dihydro-pyran-2,4-dione 
• 945619-14-7 C₂₃H₂₇ClO₅ 

Relevant articles and documents

Gold-Catalyzed Dehydrogenative Cycloisomerization of 1,4-Enyne Esters to 3,5-Disubstituted Phenol Derivatives

A method to prepare synthetically important 3,5-disubstituted phenol derivatives that relies on the sequential gold(I)-catalyzed dehydrogenative cycloisomerization of 1,4-enyne esters in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) or N-fluorobenzenesulfonimide (NFSI) is described. The synthetic versatility of the methodology was exemplified by a gram-scale reaction of one example, the ease to realize subsequent functional transformations of an adduct, and the application of the method to the synthesis of the bioactive molecule LUF5771. (Figure presented.).

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

Compounds of formula (I) are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus.