70657-65-7

Basic information

• Product Name: N-tert-Butyl-2-chlorobenzamide
• Synonyms: N-tert-Butyl-2-chlorobenzamide;BenzaMide, 2-chloro-N-(1,1-diMethylethyl)-;2-CHLORO-N-(1,1-DIMETHYLETHYL)-BENZAMIDE
• CAS NO: 70657-65-7
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.68796
• Mol File: 70657-65-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: N-tert-Butyl-2-chlorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyl-2-chlorobenzamide(70657-65-7)
• EPA Substance Registry System: N-tert-Butyl-2-chlorobenzamide(70657-65-7)

Safety Data

• Hazardous Substances Data: 70657-65-7(Hazardous Substances Data)

Usage

General Description

N-tert-Butyl-2-chlorobenzamide is a chemical compound with the molecular formula C11H14ClNO. It is a white solid that is insoluble in water and has a slightly sweet odor. N-tert-Butyl-2-chlorobenzamide is commonly used in the production of pharmaceuticals and agrochemicals, as well as in the manufacturing of dyes and pigments. It is also utilized as an intermediate in organic synthesis reactions. N-tert-Butyl-2-chlorobenzamide is considered to be relatively stable under normal conditions, but it may react with strong oxidizing agents. It should be handled with care and stored in a cool, dry place away from incompatible substances.

Upstream product

• 873-32-5 2-Chlorobenzonitrile 
• 540-88-5 acetic acid tert-butyl ester 
• 75-65-0 tert-butyl alcohol 
• 75-64-9 tert-butylamine 
• 118-91-2 ortho-chlorobenzoic acid 
• 119072-55-8 tert-butylisonitrile 
• 3033-73-6 o-chlorobenzoyl peroxide 

Downstream Products

• 118-91-2 ortho-chlorobenzoic acid 
• 1433204-03-5 2-tert-butyl-7-chloro-3-hydroxy-2,3-dihydroisoindol-1-one 
• 101494-94-4 8-chloro-2H-phthalazin-1-one 
• 1433204-04-6 8-chloro-2-(2-quinolin-2-yl-ethyl)-2H-phthalazin-1-one 

Relevant articles and documents

Weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis

The selective rearrangement of oxaziridines to amidesviaa single electron transfer (SET) pathway is unexplored. In this study, we present a weak base-promoted selective rearrangement of oxaziridines to amidesviavisible-light photoredox catalysis. The developed method shows excellent functional group tolerance with a broad substrate scope and good to excellent yields. Furthermore, control experiments and density functional theory (DFT) calculations are performed to gain insight into the reactivity and selectivity.

Atom economical synthesis of: N -alkylbenzamides via the iron(III) sulfate catalyzed rearrangement of 2-alkyl-3-aryloxaziridines in water and in the presence of a surfactant

A green and mild synthetic route to N-alkylbenzamides involves eco-friendly one pot synthesis of 2-alkyl-3-aryloxaziridines from N-alkylamines and benzaldehydes followed by iron(iii) sulfate catalyzed rearrangement to the corresponding amides in water as the solvent and in the presence of sodium dodecyl sulfate as the surfactant. This green approach affords N-alkylbenzamides in high overall yields under simple and minimum manipulation.

Bu4NI-Catalyzed Oxygen-Centered Radical Addition between Acyl Peroxides and Isocyanides

A novel oxygen-centered radical addition between acyl peroxides and isocyanides has been developed. A diverse collection of valuable arylcarboxyamides were easily synthesized by this protocol. From the preliminary mechanistic study, the elimination of carbon dioxide affords the product via an intramolecular rearrangement.