7066-19-5

Basic information

• Product Name: 6-[(3-chlorophenyl)amino]-N-ethyl-N-phenylpyridine-3-sulfonamide
• Synonyms: 3-pyridinesulfonamide, 6-[(3-chlorophenyl)amino]-N-ethyl-N-phenyl-; 6-[(3-Chlorophenyl)amino]-N-ethyl-N-phenylpyridine-3-sulfonamide
• CAS NO: 7066-19-5
• Molecular Formula: C₁₉H₁₈ClN₃O₂S
• Molecular Weight: 387.8831
• Mol File: 7066-19-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 538.7°C at 760 mmHg
• Flash Point: 279.6°C
• Density: 1.361g/cm³
• Vapor Pressure: 1.12E-11mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 6-[(3-chlorophenyl)amino]-N-ethyl-N-phenylpyridine-3-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(3-chlorophenyl)amino]-N-ethyl-N-phenylpyridine-3-sulfonamide(7066-19-5)
• EPA Substance Registry System: 6-[(3-chlorophenyl)amino]-N-ethyl-N-phenylpyridine-3-sulfonamide(7066-19-5)

Safety Data

• Hazardous Substances Data: 7066-19-5(Hazardous Substances Data)

Upstream product

• 1272661-22-9 1-chlorobenzo[f]quinazoline 
• 229-75-4 benzo[f]quinazoline 
• 454713-47-4 tert-butyl (1-bromonaphthalen-2-yl)carbamate 
• 454713-45-2 naphthalen-2-yl-carbamic acid tert-butyl ester 

Relevant articles and documents

Substituted benzoquinazolinones. Part 2: Synthesis of amino-, and sulfanyl-derivatives of benzo[f]- and benzo[h]quinazolinones

Amino- and sulfanyl-derivatives of benzoquinazolinones 16a-c, 20a-c and 21a-c were prepared under palladium-catalyzed Buchwald-Hartwig coupling reaction using bromobenzoquinazolinones 15, 19a, 19b and 1-substituted piperazines or mercaptans. The combination of Pd(OAc)2 with XantPhos proved to be the best for these conversions in the presence of KOt-Bu, in 1,4-dioxane as a solvent, at 90-100 °C. The 8-bromobenzo[f]quinazolin-1(2H)-one 15 was synthesized via condensation of the ethyl or tert-butyl 2-amino-8-bromonaphthalene-1-carboxylate 6, 10 with formamide, followed by reaction with 3,4-dimethoxybenzyl bromide. However, the 6-bromobenzo[h]quinazolin-4(3H)-ones 19a, 19b were prepared from ethyl 4-bromo-1-[(tert-butoxycarbonyl)amino]naphthalene-2-carboxylate (17). Biological screening of the potential cytotoxicity of compounds 16a, 20a, 20c on HT29 and HCT116 cell lines, has shown that compound 20a has a significant anticancer activity.