70661-86-8Relevant articles and documents
A noncatalytic approach to hetaryl-annulated 1,2,4-thiadiazine-1,1-dioxides
Cherepakha, Artem,Kovtunenko, Vladimir O.,Tolmachev, Andrey,Lukin, Oleg
, p. 1071 - 1077 (2013/10/21)
A set of synthetic procedures was developed to yield functionalized pyrido-, pyrimido-, and thiazo-annulated thiadiazine-1,1-dioxides on a preparative scale. In all cases the thiadiazine-1,1-dioxide ring closure was carried out through a reaction of hetaryl-sulfonyl chlorides with amidines under mild noncatalytic conditions. In the case of 2-chloropyridine-3-sulfonyl chloride derivatives and 2,4-dichlorothiazole-5-sulfonyl chloride open-chain sulfonylated amidine intermediates were isolated and then subjected to the cyclization step. The reaction with 2,4-dichloropyrimidine-5-sulfonyl chloride gave rise to the corresponding thiadiazine-1,1-dioxides in one-pot. Similarly, a reaction of 2-chloropyridine-3-sulfonamide with lactime ethers proceeded in one-pot readily giving the corresponding thiadiazine-1,1-dioxides. Remaining chlorine atoms on the prepared hetaryl-annulated benzothiadiazine-1,1-dioxides readily undergo aromatic nucleophilic displacement reactions serving thus as additional variation points for the design of biologically potent compounds.
