706808-37-9
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Basic information
- Product Name: belatacept
- Synonyms: belatacept
- CAS NO:706808-37-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 706808-37-9.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: belatacept(CAS DataBase Reference)
- NIST Chemistry Reference: belatacept(706808-37-9)
- EPA Substance Registry System: belatacept(706808-37-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 706808-37-9(Hazardous Substances Data)
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706808-37-9 Usage
Description
Belatacept is a recombinant immunosuppressive protein that selectively blocks T cell costimulation, providing an alternative to calcineurin inhibitors for the prophylactic prevention of rejection in kidney transplant recipients. It is a modified version of abatacept, with a higher binding affinity to CD80 and CD86, and is designed to reduce adverse effects on renal function, cardiovascular, and metabolic parameters.Uses
Used in Transplantation:Belatacept is used as an immunosuppressive agent for the prevention of allograft rejection in recipients of solid organ transplants, such as kidney transplants. It works by blocking the second signal required for T-cell activation by binding to APC costimulatory surface proteins CD80 and CD86, inhibiting their interaction with the T-cell signaling molecule CD28.
Used in Bone Marrow Transplantation:
Belatacept is used for the prevention of graft-vs-host disease following bone marrow transplantation. By inhibiting T-cell activation, it helps to prevent the immune cells from attacking the recipient's body.
Used in Autoimmune Disease Treatment:
Belatacept is used as a potential treatment for autoimmune diseases and conditions such as rheumatoid arthritis and Type 1 diabetes. Its immunosuppressive activity may help to modulate the immune system and reduce inflammation in these conditions.
Clinical Use
Prevents T-cell activation Prophylaxis of renal transplant rejectionDrug interactions
Potentially hazardous interactions with other drugs Vaccines: avoid concomitant use with live vaccines.Metabolism
Because the drug is a protein, belatacept is degraded into smaller peptides and amino acids by proteolytic enzymes.Check Digit Verification of cas no
The CAS Registry Mumber 706808-37-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,6,8,0 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.Calculate Digit Verification of CAS Registry Number 706808-37:
(8*7)+(7*0)+(6*6)+(5*8)+(4*0)+(3*8)+(2*3)+(1*7)=169
169 % 10 = 9
So 706808-37-9 is a valid CAS Registry Number.
706808-37-9Upstream product
706808-37-9Downstream Products
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belatacept
