70681-20-8

Basic information

• Product Name: (+/-)-SALSOLINOL HYDROCHLORIDE
• Synonyms: (+/-)-SALSOLINOL HYDROCHLORIDE;1-METHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE;1-METHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;(+/-)-SalsolinolHCl;DL-1-METHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE HCL;1,2,3,4-Tetrahydro-1-Methyl-;rac Salsolinol Hydrochloride
• CAS NO: 70681-20-8
• Molecular Formula: C10H14ClNO2
• Molecular Weight: 215.68
• Product Categories: Aromatics;Neurochemicals;Heterocycles
• Mol File: 70681-20-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 223-224°C
• Boiling Point: 362.6°C at 760 mmHg
• Flash Point: 175.4°C
• Appearance: yellow/powder
• Vapor Pressure: 9.13E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly, Sonicated), Water (Sparingly, Sonic
• Stability: Store in freezer at -20°C
• CAS DataBase Reference: (+/-)-SALSOLINOL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-SALSOLINOL HYDROCHLORIDE(70681-20-8)
• EPA Substance Registry System: (+/-)-SALSOLINOL HYDROCHLORIDE(70681-20-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 70681-20-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

InChI:InChI=1/C10H13NO2.ClH/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6;/h4-6,11-13H,2-3H2,1H3;1H

Upstream product

• 62-31-7 dopamine hydrochloride 
• 75-07-0 acetaldehyde 

Relevant articles and documents

Fluorometric determination of 1,2,3,4-Tetrahydro-6,7- dihydroxyisoquinoline in biological materials by HPLC

In the belief that endogenous 1,2,3,4-tetrahydro-6,7- dihydroxyisoquinoline (DA-Fp) could be a potential marker involved in the etiology of various diseases such as Parkinsonism, we attempted to develop a fluorescence method for DA-Fp. It was synthesized by condensation of dopamine with formaldehyde according to an established method. Periodate was identified by screening from various oxidation reagents as a fluorescence reagent to DA-Fp. Optimal reaction conditions were obtained with 0.25 mM NaIO4 in 0.1 M phosphate buffer (pH 8.0) at 37 °C for 15 min. The fluorescence spectrum of the derivative showed that we had found new reaction specific for DA-Fp. This reaction was coupled on-line to high performance liquid chromatography (HPLC, which enabled us to achieve a highly sensitive method for determining DA-Fp. A working curve was linear from 2 to 800 pmol of DA-Fp per injection. To determine DA-Fp in biological materials, the pretreatment before HPLC was optimized by hydrolysis of its conjugate and suppression of the artifact with l-phenylephrine. Urinary excretion of DA-Fp in men was measured by this new present method. The urinary excretion of endogenous DA-Fp increased in a rabbit given L-DOPA. The DA-Fp concentration was determined in rat brain. The significance of DA-Fp in these biological materials is discussed and evaluated. We conclude that the present method will be useful for studying tetrahydroisoquinolines involved in many diseases.

1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof

A 1,2,3,4-tetrahydroisoquinoline having the formula: SPC1 Which has relaxing activity on smooth muscles.