706819-66-1 Usage
Description
Ethanone, 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)(9CI) is a chemical compound with the molecular formula C8H8BrN3O. It is a derivative of 2-bromoacetophenone and contains a 1-methyl-1H-pyrazol-4-yl group. Ethanone, 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)(9CI) is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active compounds. It is also used in research and development for its potential pharmacological properties and therapeutic applications. However, it is important to handle this chemical with care and take necessary precautions as it may have hazardous properties.
Uses
Used in Organic Synthesis:
Ethanone, 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)(9CI) is used as a building block in organic synthesis for the creation of various pharmaceuticals and biologically active compounds. Its unique structure allows for the development of new molecules with potential applications in medicine and other fields.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Ethanone, 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)(9CI) is utilized for the synthesis of pharmaceuticals. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final product, making it a valuable component in drug discovery and development.
Used in Research and Development:
Ethanone, 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)(9CI) is also used in research and development for exploring its potential pharmacological properties and therapeutic applications. Scientists and researchers investigate its interactions with biological systems to understand its possible uses in treating various diseases and conditions.
Used in Pharmaceutical Industry:
Ethanone, 2-bromo-1-(1-methyl-1H-pyrazol-4-yl)(9CI) is used in the pharmaceutical industry as a key component in the development of new drugs. Its unique structure and properties make it a valuable asset in the creation of innovative medications with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 706819-66-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,6,8,1 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 706819-66:
(8*7)+(7*0)+(6*6)+(5*8)+(4*1)+(3*9)+(2*6)+(1*6)=181
181 % 10 = 1
So 706819-66-1 is a valid CAS Registry Number.
706819-66-1Relevant articles and documents
PYRAZOLOPYRAZINE DERIVED COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USE THEREOF
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, (2022/02/27)
Pyrazolopyrazine derived compounds as represented by general formulas (AI) and (I) or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an isotopic marker or an isomer thereof. Provided are a pharmaceutical composition comprising same and use of the compounds and the pharmaceutical composition in the preparation of medicaments for treating JAK kinase-mediated diseases. The compounds and pharmaceutical composition thereof provided have significant JAK kinase inhibitory activity, and in particular, have relatively high Tyk2 kinase inhibitory activity and selectivity for JAK2, and therefore have a very promising application potential.
Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors
Chang, Shaohua,Guo, Zhuang,Li, Xue,Sun, Tianwen,Wang, Hai,Wang, Xiaowei,Wang, Yazhou,Xu, Guofeng,Xu, Tianwei,Yu, Wenying,Yu, Zhuangzhuang,Zhang, Yan,Zhao, Liwen
supporting information, (2020/05/08)
Inhibition of transforming growth factor β (TGF-β) type 1 receptor (ALK5) provides a feasible approach for the treatment of fibrotic diseases and malignant tumors. In this study, we designed and synthesized a new series of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives, and evaluated biologically as TGF-β type 1 receptor inhibitors. The most potent compound 15r inhibited the ALK5 enzyme and NIH3T3 cell viability with IC50 values of 44 and 42.5 nM, respectively. Compound 15r also displayed better oral plasma exposure and excellent bioavailability than LY-3200882, and in vivo inhibited 65.7% of the tumor growth in a CT26 xenograft mouse model.
1,2-oxazolidine derivative and application thereof to agriculture
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Paragraph 0147-0148; 0152-0154, (2019/10/15)
The invention provides a 1,2-oxazolidine derivative and application thereof to agriculture. Concretely, the invention provides a compound shown as a formula (I) shown in the specification, a stereisomer, nitrogen oxide and salt of the compound shown as th