70684-82-1

Basic information

• Product Name: Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride
• Synonyms: Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride;1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride;METHYL 1,2,3,6-TETRAHYDROPYRIDINE-4-CARBOXYLATE HCL
• CAS NO: 70684-82-1
• Molecular Formula: C7H12ClNO2
• Molecular Weight: 177.62868
• Mol File: 70684-82-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 159-161 °C(Solv: acetonitrile (75-05-8))
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride(70684-82-1)
• EPA Substance Registry System: Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride(70684-82-1)

Safety Data

• Hazardous Substances Data: 70684-82-1(Hazardous Substances Data)

Usage

Uses

Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride?can be use to synthesize esters of isoguvacine that are potential prodrugs with weak anticonvulsant activities. It is also an intermediate for?1,2,3,6-Tetrahydro-4-pyridinemethanol (T295540) and a methyl ester of?Isoguvacine Hydrochloride (I819560).

Upstream product

• 67-56-1 methanol 
• 68547-97-7 Isoguvacine hydrochloride 

Relevant articles and documents

Esters of Isoguvacine as Potential Prodrugs

The syntheses of the methyl ester, butyl ester, (ethoxycarbonyl)methyl ester, and 11 (acyloxy)methyl esters of the potent γ-aminobutyric acid agonist isoguvacine (1,2,3,6-tetrahydropyridine-4-carboxylic acid) are described.The chemical stability of the esters and their in vitro rates of hydrolysis under approximately physiological conditions by nonspecific esterases from human serum were examined.A selected number of the esters were tested for antagonism of convulsions induced by bicuculline, isoniazide, and by electroshock.While the compounds showed only weak activities in the bicuculline and isoniazide tests, a good correlation between in vitro rates of enzymatic hydrolysis and the time of onset of the antagonism of the electroshock-induced convulsions could be found.