70684-84-3

Basic information

• Product Name: 1-Boc-1,2,3,6-tetrahydropyridine-4-carboxylic Acid
• Synonyms: 1-Boc-1,2,3,6-tetrahydropyridine-4-carboxylic Acid;3,6-DIHYDRO- 2H-PYRIDINE-1,4-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;1,4(2H)-Pyridinedicarboxylic acid, 3,6-dihydro-, 1-(1,1-dimethylethyl) ester
• CAS NO: 70684-84-3
• Molecular Formula: C₁₁H₁₇NO₄
• Molecular Weight: 227.25698
• Mol File: 70684-84-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 356.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 4.62±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-1,2,3,6-tetrahydropyridine-4-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-1,2,3,6-tetrahydropyridine-4-carboxylic Acid(70684-84-3)
• EPA Substance Registry System: 1-Boc-1,2,3,6-tetrahydropyridine-4-carboxylic Acid(70684-84-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN2811
• Hazardous Substances Data: 70684-84-3(Hazardous Substances Data)

Usage

Uses

1-Boc-1,2,3,6-tetrahydropyridine-4-carboxylic Acid is a useful research chemical.

Upstream product

• 124-38-9 carbon dioxide 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 1146955-04-5 4-bromo-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 307496-27-1 2-bromobenzylzinc(II) bromide 

Downstream Products

• 906663-33-0 3-benzylsulfanyl-4-[1-(1-benzylsulfanylmethyl-4-butylcarbamoyl-2-hydroxypentylcarbamoyl)ethylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester 
• 906663-27-2 3-benzylsulfanyl-4-[1-(1-benzylsulfanylmethyl-4-butylcarbamoyl-2-hydroxypentylcarbamoyl)ethylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester 
• 1025943-09-2 (Z)-3-Hydroxy-2-methyl-1-(1-phenethyl-1,2,3,6-tetrahydro-pyridin-4-yl)-3-phenyl-propenone 
• 184368-74-9 3,6-dihydro-2H-pyridine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester 

Relevant articles and documents

Formation of quaternary carbons through cobalt-catalyzed C(sp3)-C(sp3) Negishi cross-coupling

Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry. We report a cobalt-catalyzed C(sp3)-C(sp3) cross-coupling that allows for the introduction of benzyl, heteroarylmethylzinc and allyl groups to halo-carbonyl substrates. The cross-coupling reaction is selective for C(sp3)-over C(sp2)-halides, in contrast to most used catalytic metals, and allows access to novel scaffolds of pharmaceutical interest. NMR mechanistic studies suggest the presence of Co(0) complexes as catalytic species. This journal is