70696-57-0

Basic information

• Product Name: 4-methoxy-1-naphthoyl chloride
• Synonyms: 4-methoxy-1-naphthoyl chloride;4-Methoxy-1-naphthalenecarbonyl Chloride
• CAS NO: 70696-57-0
• Molecular Formula: C₁₂H₉ClO₂
• Molecular Weight: 221
• EINECS: -0
• Product Categories: Aromatics;Intermediates
• Mol File: 70696-57-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methoxy-1-naphthoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-1-naphthoyl chloride(70696-57-0)
• EPA Substance Registry System: 4-methoxy-1-naphthoyl chloride(70696-57-0)

Safety Data

• Hazardous Substances Data: 70696-57-0(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

4-methoxy-1-naphthoyl chloride is used in the preparation of isoindole derivatives for treatment of gastrointestinal diseases.

Upstream product

• 13041-62-8 4-methoxy-1-naphthoic acid 
• 15971-29-6 4-methoxy-1-naphthaldehyde 
• 5961-55-7 4-methoxy-1-naphthalenecarbonitrile 

Downstream Products

• 166599-76-4 3-(4-methoxynaphthalene-1-carbonyl)-1-[2-(morpholin-4-yl)ethyl]-1H-indole 
• 316189-74-9 (4-methoxy-1-naphthalenyl)(2-methyl-1-pentyl1H-indol-3-yl)methanone 
• 745821-84-5 4-methoxy-naphthalene-1-carboxylic acid (3-fluoro-phenyl)-amide 
• 745821-85-6 [4-(3-fluoro-phenylcarbamoyl)-naphthalen-1-yloxy]-acetic acid methyl ester 
• 745821-86-7 [4-(3-fluoro-phenylcarbamoyl)-naphthalen-1-yloxy]-acetic acid 

Relevant articles and documents

Palladium-catalyzed directing group-assisted C8-triflation of naphthalenes

The transition-metal-catalyzed direct triflation of naphthyl amides and naphthyl ketones has been accomplished for the first time. Benzophenone (BP) was found to be a suitable ligand for the cross-coupling reactions. Density functional theory (DFT) calculations revealed that excessive amounts of HOTf inhibit the reductive elimination of the C-F bond to realize the unusual reductive elimination of the C-OTf bond.

ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER

Compounds of formula I or pharmaceutically acceptable salts thereof: [Chemical formula should be inserted here. Please see paper copy] I wherein X, R1, R2, R3, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds

The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to