707-17-5

Basic information

• Product Name: 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE
• Synonyms: AKOS BBS-00006332;8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE
• CAS NO: 707-17-5
• Molecular Formula: C₉H₁₄N₂O₂
• Molecular Weight: 182.22
• Mol File: 707-17-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.2g/cm³
• Refractive Index: 1.537
• CAS DataBase Reference: 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE(707-17-5)
• EPA Substance Registry System: 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE(707-17-5)

Safety Data

• Hazardous Substances Data: 707-17-5(Hazardous Substances Data)

Usage

General Description

8-Methyl-1,3-diazaspiro[4.5]decane-2,4-dione is a chemical compound with the molecular formula C9H15N3O2. 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE is a spirodiketopiperazine, which is a class of natural products with diverse biological activities. It is commonly used in organic synthesis and medicinal chemistry for the development of new drugs and pharmaceuticals. The compound has potential applications in the treatment of various diseases and conditions, and its unique chemical structure makes it an interesting target for further research and development.

InChI:InChI=1/C9H14N2O2/c1-6-2-4-9(5-3-6)7(12)10-8(13)11-9/h6H,2-5H2,1H3,(H2,10,11,12,13)

Upstream product

• 151-50-8 potassium cyanide 
• 589-92-4 1-methylcyclohexan-4-one 
• 506-87-6 ammonium carbonate 
• 461-37-0 2,2,2-trifluoroethyl carbamate 
• 773837-37-9 sodium cyanide 

Downstream Products

• 69164-35-8 1-amino-4-methyl-cyclohexanecarboxylic acid 
• 199330-69-3 1-tert-Butoxycarbonylamino-4-methyl-cyclohexanecarboxylic acid 
• 199330-70-6 1-[(1-tert-Butoxycarbonylamino-4-methyl-cyclohexanecarbonyl)-amino]-4-methyl-cyclohexanecarboxylic acid methyl ester 
• 1361251-56-0 3-[(9,10-dihydro-9,10-dioxo-2-anthracenyl)sulfonyl]-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1202159-90-7 3-(4-chlorophenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1361251-52-6 8-methyl-3-(4-methylphenylsulfonyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1361251-54-8 3-(4-methoxyphenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1202158-76-6 3-(4-bromophenylsulfonyl)-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1361251-53-7 8-methyl-3-(4-nitrophenylsulfonyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 16252-93-0 3-amino-8-methyl-1,3-diaza-spiro[4.5]decane-2,4-dione 

Relevant articles and documents

Synthesis, characterization and antimicrobial activity of nalidixic acid derivatives with spirohydantoins

This article presents the synthesis of a series of amides, based on the interaction of several 3-aminospirohydantoins with nalidixic acid. The target compounds were characterized by physicochemical parameters, IR, 1H and 13C NMR spectral data. The antimicrobial activity of the products obtained was determined against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and Salmonella abony, the yeasts Candida albicans and Saccharomyces cerevisiae and the molds Penicillium chrysogenum and Aspergillus niger. The relationship between structure and biological activity of the products obtained was discussed. It was found that the most effective compounds are tetralin (5f) and indane (5g) derivatives, which exhibit a pronounced antimicrobial activity against both tested Gram-positive and Gram-negative bacteria.

Synthesis, characterization, and hypoglycemic activity of 3-(arylsulfonyl)spiroimidazolidine-2,4-diones

Spiroimidazolidine-2,4-diones were prepared from methylcyclohexanones by the Bucherer-Bergs reaction. Synthesis of the target 3-(arylsulfonyl) spiroimidazolidine-2,4-diones was achieved by reaction of arylsulfonyl chlorides with corresponding spiroimidazolidine-2,4-diones. The synthesis was confirmed by spectroanalytical techniques and the crystal structure of 3-(4-methoxyphenylsulfonyl)-6-methyl-1,3-diazaspiro[4.5]decane-2,4-dione, and the purity was checked by GC-MS analysis. The in-vivo hypoglycemic potential of 6-methyl-, 7-methyl-, and 8-methyl-3-(4-methylphenylsulfonyl)-1,3-diazaspiro[4. 5]decane-2,4-dione was investigated on male albino rats. The screened compounds were found to have excellent hypoglycemic activity. 6-Methyl-3-(4- methylphenylsulfonyl)-1,3-diazaspiro[4.5]decane-2,4-dione was found highly active, reducing the blood glucose level by 60.79% compared with 41.60% by the standard (glipizide) at a dose level of 100 mg/kg of the mice body weight. The 8-methyl isomer was also more potent than the standard, with 48.56% reduction in blood glucose level.