70708-34-8

Basic information

• Product Name: (±)-2,3-diphenylpiperazine
• CAS NO: 70708-34-8
• Molecular Weight: 238.332
• Mol File: 70708-34-8.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (±)-2,3-diphenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-2,3-diphenylpiperazine(70708-34-8)
• EPA Substance Registry System: (±)-2,3-diphenylpiperazine(70708-34-8)

Safety Data

• Hazardous Substances Data: 70708-34-8(Hazardous Substances Data)

Upstream product

• 1489-06-1 2,3-diphenyl-5,6-dihydropyrazine 
• 1588-89-2 2,3-diphenylpyrazine 
• 123-51-3 i-Amyl alcohol 
• 134-81-6 benzil 
• 951-87-1 rac-1,2-diphenylethylene-1,2-diamine 
• 107-21-1 ethylene glycol 
• 104-71-2 N,N'-bis(benzyliden)ethylendiamine 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 116360-40-8 N-<(tri-n-butylstannyl)methyl>benzaldimine 
• 110-83-8 cyclohexene 
• 104-71-2 (1E,1’E)-N,N’-(ethane-1,2-diyl)bis(1-phenylmethanimine) 

Downstream Products

• 1376191-63-7 (R,R)-tert-butyl-4-benzyl-2,3-diphenyl-1-piperazinecarboxylate 
• 1376189-45-5 (R,R)-1-benzyl-2,3-diphenylpiperazine 
• 1376191-29-5 (3R,4R)-8-octyl-3,4,6-triphenyl-3,4-dihydropyrrolo[1,2-a]pyrazine 
• 1376191-82-0 C₃₈H₃₄N₂ 
• 1241681-30-0 (R,R)-tert-butyl-2,3-diphenyl-1-piperazinecarboxylate 
• 81401-24-3 trans-2,3-diphenyl-1,4-diazabicyclo<2.2.2>octane 
• 81577-03-9 piperazine-2,3 diphenyl N,N-dimethyl trans 

Relevant articles and documents

A facile synthesis of vicinal diamines promoted by low-valent niobium: Preparation of chiral octahydrobiisoquinolines and their application to catalytic asymmetric synthesis

An efficient homocoupling of imines to give vicinal diamines promoted by low-valent niobium, generated by treatment of NbCl5 with zinc powder, is described. The desired products were obtained in good to excellent yields. Dihydroisoquinoline derivatives also gave the coupling products with good diastereoselectivities (D,L/meso). Optical resolution of the racemic octahydrobiisoquinolines was achieved and their complexes with Cu1 used in the catalytic asymmetric oxidative coupling of β-naphthols. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

YbCl3-catalyzed one-pot synthesis of dihydropyrazines, piperazines, and pyrazines

A simple and efficient synthetic approach to dihydropyrazines via YbCl 3-catalyzed reaction of α-hydroxyketones with diamines under mild conditions was developed. The corresponding 2,3-subsitituted piperazines and pyrazines were obtained through tandem conversion of dihydropyrazines with good yields.

A new Yb3+-catalyzed pinacol and imine-coupling reaction

Ytterbium triflate, Yb(OTf)3, catalyzes the intermolecular reductive homocouplings of imines, aldehydes, and ketones at loadings of 5 mol % in the presence of Mg and Me3SiCl to give isolated yields of up to 95%. Diastereoselectivity of up to 4/96 (dl/meso) is achieved for aromatic aldehydes, up to 100% dl for aliphatic aldehydes, and 100% dl for an intramolecular imine coupling.